diff --git a/.github/workflows/ci_mac.yml b/.github/workflows/ci_mac.yml
index de71691a18..c2bc63c4ab 100644
--- a/.github/workflows/ci_mac.yml
+++ b/.github/workflows/ci_mac.yml
@@ -232,7 +232,7 @@ jobs:
         # used by std::vector<>::insert().
         export ASAN_OPTIONS='fast_unwind_on_malloc=0 detect_container_overflow=0'
         # Exclude tests that are currently known to fail
-        wx_tests_selection='~[.] ~[valnum] ~wxPersistTLW ~wxPersistDVC ~wxTopLevel::Show ~wxFont::Weight ~wxFont::NativeFontInfo ~WebView ~RadioButton::Single ~RadioButton::Focus ~wxHtmlPrintout::Pagination ~wxTextCtrl::GetBestSize ~TextCtrlTestCase ~wxExecute::RedirectUTF8 ~Ellipsization::NormalCase ~SpinCtrl::* ~SpinCtrlDouble::* ~NotebookTestCase ~SettingsTestCase ~Window::Show ~ModalDialogsTestCase ~Button::Click ~Button::Disabled ~wxDVC::GetItemRect ~wxDVC::AppendTextColumn ~Grid::KeyboardSelection ~Grid::CellClick ~Grid::ReorderedColumnsCellClick ~Grid::CellSelect ~wxStyledTextCtrl::AutoComp ~EvtLoopTestCase ~EventPropagationTestCase ~wxTreeCtrl::ItemClick ~wxTreeCtrl::LabelEdit ~wxTreeCtrl::KeyDown ~wxTreeCtrl::CollapseExpandEvents ~wxTreeCtrl::SelectionChange ~wxTreeCtrl::Menu ~wxTreeCtrl::KeyNavigation'
+        wx_tests_selection='~[.] ~[valnum] ~wxPersistTLW ~wxPersistDVC ~wxTopLevel::Show ~wxFont::Weight ~wxFont::NativeFontInfo ~WebView ~RadioButton::Single ~RadioButton::Focus ~wxHtmlPrintout::Pagination ~wxTextCtrl::GetBestSize ~TextCtrlTestCase ~wxExecute::RedirectUTF8 ~Ellipsization::NormalCase ~SpinCtrl::* ~SpinCtrlDouble::* ~NotebookTestCase ~SettingsTestCase ~Window::Show ~ModalDialogsTestCase ~Button::Click ~Button::Disabled ~wxDVC::GetItemRect ~wxDVC::AppendTextColumn ~Grid::KeyboardSelection ~Grid::CellClick ~Grid::ReorderedColumnsCellClick ~Grid::CellSelect ~wxStyledTextCtrl::AutoComp ~EvtLoopTestCase ~EventPropagationTestCase ~wxTreeCtrl::ItemClick ~wxTreeCtrl::LabelEdit ~wxTreeCtrl::KeyDown ~wxTreeCtrl::CollapseExpandEvents ~wxTreeCtrl::SelectionChange ~wxTreeCtrl::SelectItemMultiInteractive ~wxTreeCtrl::Menu ~wxTreeCtrl::KeyNavigation'
         ./test_gui.app/Contents/MacOS/test_gui $wx_tests_selection
 
     - name: Building samples
diff --git a/tests/controls/treectrltest.cpp b/tests/controls/treectrltest.cpp
index a7ac6ce608..65e71e9bda 100644
--- a/tests/controls/treectrltest.cpp
+++ b/tests/controls/treectrltest.cpp
@@ -25,6 +25,7 @@
 #include "wx/treectrl.h"
 #include "wx/uiaction.h"
 #include "testableframe.h"
+#include "waitfor.h"
 
 // ----------------------------------------------------------------------------
 // test class
@@ -58,6 +59,7 @@ public:
     }
 
 protected:
+
     // the tree control itself
     wxTreeCtrl *m_tree = nullptr;
 
@@ -400,6 +402,81 @@ TEST_CASE_METHOD(TreeCtrlTestCase, "wxTreeCtrl::SelectionChange", "[treectrl]")
     }
 }
 
+TEST_CASE_METHOD(TreeCtrlTestCase, "wxTreeCtrl::SelectItemMultiInteractive", "[treectrl]")
+{
+#if defined(__WXGTK__) && !defined(__WXGTK3__)
+    // FIXME: This test fails on GitHub CI under wxGTK2 although works fine on
+    //        development machine, no idea why though!
+    if ( IsAutomaticTest() )
+        return;
+#endif // wxGTK2
+
+    // this test should be only ran in multi-selection control
+    m_tree->ToggleWindowStyle(wxTR_MULTIPLE);
+
+    m_tree->ExpandAll();
+
+    // This is currently needed to work around a problem under wxMSW: clicking
+    // on an item in an unfocused control generates two selection change events
+    // because of the SetFocus() call in TVN_SELCHANGED handler in wxMSW code.
+    // This is, of course, wrong on its own, but fixing it without breaking
+    // anything else is non-obvious, so for now at least work around this
+    // problem in the test.
+    m_tree->SetFocus();
+
+    EventCounter beginedit(m_tree, wxEVT_TREE_BEGIN_LABEL_EDIT);
+
+    wxUIActionSimulator sim;
+
+    wxRect poschild1, poschild2;
+    m_tree->GetBoundingRect(m_child1, poschild1, true);
+    m_tree->GetBoundingRect(m_child2, poschild2, true);
+
+    // We move in slightly so we are not on the edge
+    wxPoint point1 = m_tree->ClientToScreen(poschild1.GetPosition()) + wxPoint(4, 4);
+    wxPoint point2 = m_tree->ClientToScreen(poschild2.GetPosition()) + wxPoint(4, 4);
+
+    sim.MouseMove(point1);
+    wxYield();
+
+    sim.MouseClick();
+    wxYield();
+
+    sim.MouseMove(point2);
+    wxYield();
+
+    sim.KeyDown(WXK_CONTROL);
+    sim.MouseClick();
+    sim.KeyUp(WXK_CONTROL);
+    wxYield();
+
+    // m_child1 and m_child2 should be selected.
+    CHECK( m_tree->IsSelected(m_child1) );
+    CHECK( m_tree->IsSelected(m_child2) );
+    CHECK( beginedit.GetCount() == 0 );
+
+    // Time needed (in ms) for the editor to display. The test will not pass
+    // if the value is less than 400, 510, 800 under wxQt, wxGTK, wxMSW resp.
+    const int BEGIN_EDIT_TIMEOUT = 800;
+
+    YieldForAWhile(BEGIN_EDIT_TIMEOUT);
+    sim.MouseClick();
+    YieldForAWhile(BEGIN_EDIT_TIMEOUT);
+
+    // Only m_child2 should be selected now.
+    CHECK_FALSE( m_tree->IsSelected(m_child1) );
+    CHECK( m_tree->IsSelected(m_child2) );
+    CHECK( beginedit.GetCount() == 0 ); // No editing should take place in the event of deselection.
+
+    sim.MouseClick();
+    YieldForAWhile(BEGIN_EDIT_TIMEOUT);
+
+    CHECK( beginedit.GetCount() == 1 ); // Start editing as usual.
+
+    sim.Char(WXK_RETURN); // End editing and close the editor.
+    wxYield();
+}
+
 TEST_CASE_METHOD(TreeCtrlTestCase, "wxTreeCtrl::Menu", "[treectrl]")
 {
     EventCounter menu(m_tree, wxEVT_TREE_ITEM_MENU);