diff --git a/conf/firmwares/lisa_passthrough.makefile b/conf/firmwares/lisa_passthrough.makefile
index d564d9f83a..c096ef3dfa 100644
--- a/conf/firmwares/lisa_passthrough.makefile
+++ b/conf/firmwares/lisa_passthrough.makefile
@@ -112,8 +112,7 @@ stm_passthrough.CFLAGS += -DUSE_AD1 \
     -DUSE_AD1_1 \
     -DUSE_AD1_2 \
     -DUSE_AD1_3 \
-    -DUSE_AD1_4 \
-    -DUSE_ADC1_2_IRQ_HANDLER
+    -DUSE_AD1_4
 
 
 # Battery monitor
diff --git a/conf/firmwares/lisa_test_progs.makefile b/conf/firmwares/lisa_test_progs.makefile
index 25e0b1f437..2617c59ca1 100644
--- a/conf/firmwares/lisa_test_progs.makefile
+++ b/conf/firmwares/lisa_test_progs.makefile
@@ -263,7 +263,6 @@ test_adc.CFLAGS += -I$(SRC_LISA)
 test_adc.srcs   += $(SRC_LISA)/test_adc.c
 test_adc.srcs   += $(SRC_ARCH)/mcu_periph/adc_arch.c
 test_adc.CFLAGS += -DUSE_AD1 -DUSE_AD1_1 -DUSE_AD1_2 -DUSE_AD1_3 -DUSE_AD1_4
-test_adc.CFLAGS += -DUSE_ADC1_2_IRQ_HANDLER
 
 
 ##################################################
diff --git a/conf/firmwares/subsystems/fixedwing/autopilot.makefile b/conf/firmwares/subsystems/fixedwing/autopilot.makefile
index c61bfb80cd..b92c358131 100644
--- a/conf/firmwares/subsystems/fixedwing/autopilot.makefile
+++ b/conf/firmwares/subsystems/fixedwing/autopilot.makefile
@@ -139,7 +139,6 @@ ns_CFLAGS 		+= -DUSE_ADC
   ns_srcs 		+= $(SRC_ARCH)/mcu_periph/adc_arch.c
 ifeq ($(ARCH), stm32)
   ns_CFLAGS 		+= -DUSE_AD1 -DUSE_AD1_1 -DUSE_AD1_2 -DUSE_AD1_3 -DUSE_AD1_4
-  ns_CFLAGS 		+= -DUSE_ADC1_2_IRQ_HANDLER
 endif
 
 ######################################################################