diff --git a/boards/arm/stm32/nucleo-l152re/include/board.h b/boards/arm/stm32/nucleo-l152re/include/board.h
index d1e29b4efe6..e553ebd1425 100644
--- a/boards/arm/stm32/nucleo-l152re/include/board.h
+++ b/boards/arm/stm32/nucleo-l152re/include/board.h
@@ -221,4 +221,9 @@
 #define GPIO_SPI1_MISO   GPIO_SPI1_MISO_2
 #define GPIO_SPI1_SCK    GPIO_SPI1_SCK_1
 
+/* I2C1 */
+
+#define GPIO_I2C1_SCL    GPIO_I2C1_SCL_2  /* PB8  CN5 pin 10, D15 */
+#define GPIO_I2C1_SDA    GPIO_I2C1_SDA_2  /* PB9  CN5 pin 9, D14 */
+
 #endif /* __BOARDS_ARM_STM32_NUCLEO_L152RE_INCLUDE_BOARD_H */
diff --git a/boards/arm/stm32/nucleo-l152re/src/stm32_appinitialize.c b/boards/arm/stm32/nucleo-l152re/src/stm32_appinitialize.c
index 6b146d53bcb..e0c8ca2b866 100644
--- a/boards/arm/stm32/nucleo-l152re/src/stm32_appinitialize.c
+++ b/boards/arm/stm32/nucleo-l152re/src/stm32_appinitialize.c
@@ -26,11 +26,14 @@
 
 #include <sys/types.h>
 #include <syslog.h>
+#include <debug.h>
 
 #include <nuttx/board.h>
 #include <nuttx/fs/fs.h>
 #include <nuttx/leds/userled.h>
 
+#include "stm32_i2c.h"
+
 #include "nucleo-l152re.h"
 
 /****************************************************************************
@@ -80,6 +83,52 @@
 int board_app_initialize(uintptr_t arg)
 {
   int ret;
+#ifdef CONFIG_STM32_I2C1
+  FAR struct i2c_master_s *i2c1;
+#endif
+#ifdef CONFIG_STM32_I2C2
+  FAR struct i2c_master_s *i2c2;
+#endif
+
+#ifdef CONFIG_STM32_I2C1
+  /* Get the I2C lower half instance */
+
+  i2c1 = stm32_i2cbus_initialize(1);
+  if (i2c1 == NULL)
+    {
+      i2cerr("ERROR: Initialize I2C1: %d\n", ret);
+    }
+  else
+    {
+      /* Register the I2C character driver */
+
+      ret = i2c_register(i2c1, 1);
+      if (ret < 0)
+        {
+          i2cerr("ERROR: Failed to register I2C1 device: %d\n", ret);
+        }
+    }
+#endif
+
+#ifdef CONFIG_STM32_I2C2
+  /* Get the I2C lower half instance */
+
+  i2c2 = stm32_i2cbus_initialize(2);
+  if (i2c2 == NULL)
+    {
+      i2cerr("ERROR: Initialize I2C2: %d\n", ret);
+    }
+  else
+    {
+      /* Register the I2C character driver */
+
+      ret = i2c_register(i2c2, 2);
+      if (ret < 0)
+        {
+          i2cerr("ERROR: Failed to register I2C2 device: %d\n", ret);
+        }
+    }
+#endif
 
 #ifdef HAVE_LEDS
   /* Register the LED driver */
diff --git a/boards/arm/stm32/nucleo-l152re/src/stm32_boot.c b/boards/arm/stm32/nucleo-l152re/src/stm32_boot.c
index 19a9a201ec6..2d2b55ca8df 100644
--- a/boards/arm/stm32/nucleo-l152re/src/stm32_boot.c
+++ b/boards/arm/stm32/nucleo-l152re/src/stm32_boot.c
@@ -68,3 +68,25 @@ void stm32_boardinitialize(void)
   board_autoled_initialize();
 #endif
 }
+
+/****************************************************************************
+ * Name: board_late_initialize
+ *
+ * Description:
+ *   If CONFIG_BOARD_LATE_INITIALIZE is selected, then an additional
+ *   initialization call will be performed in the boot-up sequence to a
+ *   function called board_late_initialize(). board_late_initialize() will be
+ *   called immediately after up_initialize() is called and just before the
+ *   initial application is started.  This additional initialization phase
+ *   may be used, for example, to initialize board-specific device drivers.
+ *
+ ****************************************************************************/
+
+#ifdef CONFIG_BOARD_LATE_INITIALIZE
+void board_late_initialize(void)
+{
+  /* Perform board-specific initialization */
+
+  board_app_initialize(0);
+}
+#endif