diff --git a/arch/sim/src/sim/up_initialstate.c b/arch/sim/src/sim/up_initialstate.c
index 1b11ebb0509..eba0bd14d71 100644
--- a/arch/sim/src/sim/up_initialstate.c
+++ b/arch/sim/src/sim/up_initialstate.c
@@ -26,6 +26,9 @@
 
 #include <stdint.h>
 #include <string.h>
+#ifdef CONFIG_SIM_ASAN
+#include <sanitizer/asan_interface.h>
+#endif
 
 #include <nuttx/arch.h>
 
@@ -83,4 +86,7 @@ void up_initial_state(struct tcb_s *tcb)
                                      tcb->adj_stack_size -
                                      sizeof(xcpt_reg_t);
   tcb->xcp.regs[JB_PC] = (xcpt_reg_t)tcb->start;
+#ifdef CONFIG_SIM_ASAN
+  __asan_unpoison_memory_region(tcb->stack_alloc_ptr, tcb->adj_stack_size);
+#endif
 }