diff --git a/arch/sim/src/sim/posix/sim_libusb.c b/arch/sim/src/sim/posix/sim_libusb.c
index bf745c499c0..d99021248c1 100644
--- a/arch/sim/src/sim/posix/sim_libusb.c
+++ b/arch/sim/src/sim/posix/sim_libusb.c
@@ -286,8 +286,11 @@ static void host_libusb_inttransfer_cb(struct libusb_transfer *transfer)
 #ifndef CONFIG_USBHOST_ISOC_DISABLE
 static void host_libusb_isotransfer_cb(struct libusb_transfer *transfer)
 {
-  struct host_libusb_hostdev_s *dev = &g_libusb_dev;
+  struct libusb_iso_packet_descriptor *packet;
   struct host_usb_datareq_s *datareq;
+  usbhost_asynch_t callback;
+  size_t length;
+  int i;
 
   if (!transfer)
     {
@@ -298,18 +301,24 @@ static void host_libusb_isotransfer_cb(struct libusb_transfer *transfer)
     }
 
   datareq = (struct host_usb_datareq_s *)transfer->user_data;
+  callback = datareq->callback;
 
-  if (transfer->status == LIBUSB_TRANSFER_COMPLETED)
+  for (i = 0; i < transfer->num_iso_packets; i++)
     {
-      datareq->success = true;
-      datareq->xfer += transfer->actual_length;
-    }
-  else
-    {
-      datareq->success = false;
+      packet = &transfer->iso_packet_desc[i];
+      length = packet->status == LIBUSB_TRANSFER_COMPLETED ?
+                                      packet->actual_length : 0;
+
+      /* If there are multiple isoc packages, only the actual length
+       * of the data in each package is returned here. Because each
+       * package has the same size, the number of packages returned
+       * needs to be recorded in class driver.
+       */
+
+      callback(datareq->priv, length);
     }
 
-  host_libusb_fifopush(&dev->completed, datareq);
+  free(datareq);
   host_uninterruptible_no_return(libusb_free_transfer, transfer);
 }
 #endif
@@ -486,9 +495,7 @@ host_libusb_isotransfer(struct host_libusb_hostdev_s *dev, uint8_t addr,
   int num_iso_pack;
   int ret;
 
-  max_packet_size = host_uninterruptible(libusb_get_max_iso_packet_size,
-                                         dev->priv,
-                                         addr);
+  max_packet_size = datareq->maxpacketsize;
   num_iso_pack = (datareq->len + max_packet_size - 1) / max_packet_size;
   transfer = host_uninterruptible(libusb_alloc_transfer, num_iso_pack);
   if (!transfer)
diff --git a/arch/sim/src/sim/sim_usbhost.c b/arch/sim/src/sim/sim_usbhost.c
index 65931cd7632..8c559fcd03e 100644
--- a/arch/sim/src/sim/sim_usbhost.c
+++ b/arch/sim/src/sim/sim_usbhost.c
@@ -77,9 +77,9 @@ struct sim_epinfo_s
   uint8_t toggle:1;            /* Next data toggle */
   uint8_t interval;            /* Polling interval */
   uint8_t status;              /* Retained token status bits (for debug purposes) */
-  uint16_t maxpacket:11;       /* Maximum packet size */
+  uint16_t maxpacket:14;       /* Maximum packet size */
   uint16_t xfrtype:2;          /* See USB_EP_ATTR_XFER_* definitions in usb.h */
-  uint16_t speed:2;            /* See USB_*_SPEED definitions */
+  uint8_t speed;               /* See USB_*_SPEED definitions */
   int result;                  /* The result of the transfer */
   ssize_t xfrd;                /* On completion, will hold the number of bytes transferred */
   sem_t iocsem;                /* Semaphore used to wait for transfer completion */
@@ -406,7 +406,8 @@ static int sim_usbhost_epalloc(struct usbhost_driver_s *drvr,
   epinfo->dirin     = epdesc->in;
   epinfo->devaddr   = hport->funcaddr;
   epinfo->interval  = epdesc->interval;
-  epinfo->maxpacket = epdesc->mxpacketsize;
+  epinfo->maxpacket = (epdesc->mxpacketsize & USB_EP_MAXP_MASK) *
+                      (USB_EP_MAX_PACKET_MULT(epdesc->mxpacketsize) + 1);
   epinfo->xfrtype   = epdesc->xfrtype;
   epinfo->speed     = hport->speed;
   nxsem_init(&epinfo->iocsem, 0, 0);
@@ -610,6 +611,7 @@ static int sim_usbhost_asynch(struct usbhost_driver_s *drvr,
   datareq->addr = (epinfo->dirin << 7) + epinfo->epno;
   datareq->len = buflen;
   datareq->xfrtype = epinfo->xfrtype;
+  datareq->maxpacketsize = epinfo->maxpacket;
   datareq->callback = callback;
   datareq->data = buffer;
   datareq->priv = arg;
diff --git a/arch/sim/src/sim/sim_usbhost.h b/arch/sim/src/sim/sim_usbhost.h
index 9db8c583954..b559a6debe0 100644
--- a/arch/sim/src/sim/sim_usbhost.h
+++ b/arch/sim/src/sim/sim_usbhost.h
@@ -78,6 +78,7 @@ struct host_usb_datareq_s
   struct host_usb_datareq_s  *flink;
   uint8_t                     addr;
   uint8_t                     xfrtype;
+  uint16_t                    maxpacketsize;
   uint8_t                    *data;
   uint16_t                    len;
   uint16_t                    xfer;
diff --git a/include/nuttx/usb/usb.h b/include/nuttx/usb/usb.h
index d9bffad3ce6..9bc96ca2314 100644
--- a/include/nuttx/usb/usb.h
+++ b/include/nuttx/usb/usb.h
@@ -256,6 +256,14 @@
 #  define USB_EP_ATTR_USAGE_IMPLICIT            (2 << USB_EP_ATTR_USAGE_SHIFT)
 #define USB_EP_ATTR_MAX_ADJUSTABLE              (1 << 7)
 
+/* Endpoint descriptor max packet size */
+
+#define USB_EP_MAX_PACKET_MASK                  (0x07ff)
+#define USB_EP_MAX_PACKET_MULT_SHIFT            (11)
+#define USB_EP_MAX_PACKET_MULT_MASK             (3 << USB_EP_MAX_PACKET_MULT_SHIFT)
+#define USB_EP_MAX_PACKET_MULT(m)               (((m) & USB_EP_MAX_PACKET_MULT_MASK) >> \
+                                                 USB_EP_MAX_PACKET_MULT_SHIFT)
+
 /* OTG Definitions */
 
 /* OTG SET FEATURE Constants */