diff --git a/drivers/serial/serial_dma.c b/drivers/serial/serial_dma.c
index 17c453a79a4..de82c9c1465 100644
--- a/drivers/serial/serial_dma.c
+++ b/drivers/serial/serial_dma.c
@@ -193,11 +193,18 @@ void uart_xmitchars_done(FAR uart_dev_t *dev)
   size_t nbytes = xfer->nbytes;
   struct uart_buffer_s *txbuf = &dev->xmit;
 
-  /* Move tail for nbytes. */
+  /* Skip the update if the tail position change which mean
+   * someone reset (e.g. TCOFLUSH) the xmit buffer during DMA.
+   */
 
-  txbuf->tail  = (txbuf->tail + nbytes) % txbuf->size;
-  xfer->nbytes = 0;
-  xfer->length = xfer->nlength = 0;
+  if (xfer->buffer == &txbuf->buffer[txbuf->tail])
+    {
+      /* Move tail for nbytes. */
+
+      txbuf->tail  = (txbuf->tail + nbytes) % txbuf->size;
+      xfer->nbytes = 0;
+      xfer->length = xfer->nlength = 0;
+    }
 
   /* If any bytes were removed from the buffer, inform any waiters there there is
    * space available.