diff --git a/arch/sim/src/sim/posix/sim_hostfs.c b/arch/sim/src/sim/posix/sim_hostfs.c
index a22d7118d32..8597b036f1c 100644
--- a/arch/sim/src/sim/posix/sim_hostfs.c
+++ b/arch/sim/src/sim/posix/sim_hostfs.c
@@ -194,7 +194,13 @@ int host_open(const char *pathname, int flags, int mode)
       mapflags |= O_DIRECTORY;
     }
 
-  return host_uninterruptible_errno(open, pathname, mapflags, mode);
+  int ret = open(pathname, mapflags, mode);
+  if (ret == -1)
+    {
+      ret = host_errno_convert(-errno);
+    }
+
+  return ret;
 }
 
 /****************************************************************************
@@ -205,7 +211,13 @@ int host_close(int fd)
 {
   /* Just call the close routine */
 
-  return host_uninterruptible_errno(close, fd);
+  int ret = close(fd);
+  if (ret == -1)
+    {
+      ret = host_errno_convert(-errno);
+    }
+
+  return ret;
 }
 
 /****************************************************************************
@@ -216,7 +228,13 @@ nuttx_ssize_t host_read(int fd, void *buf, nuttx_size_t count)
 {
   /* Just call the read routine */
 
-  return host_uninterruptible_errno(read, fd, buf, count);
+  nuttx_ssize_t ret = read(fd, buf, count);
+  if (ret == -1)
+    {
+      ret = host_errno_convert(-errno);
+    }
+
+  return ret;
 }
 
 /****************************************************************************
@@ -227,7 +245,13 @@ nuttx_ssize_t host_write(int fd, const void *buf, nuttx_size_t count)
 {
   /* Just call the write routine */
 
-  return host_uninterruptible_errno(write, fd, buf, count);
+  nuttx_ssize_t ret = write(fd, buf, count);
+  if (ret == -1)
+    {
+      ret = host_errno_convert(-errno);
+    }
+
+  return ret;
 }
 
 /****************************************************************************
@@ -239,7 +263,13 @@ nuttx_off_t host_lseek(int fd, nuttx_off_t pos, nuttx_off_t offset,
 {
   /* Just call the lseek routine */
 
-  return host_uninterruptible_errno(lseek, fd, offset, whence);
+  nuttx_off_t ret = lseek(fd, offset, whence);
+  if (ret == (nuttx_off_t)-1)
+    {
+      ret =  host_errno_convert(-errno);
+    }
+
+  return ret;
 }
 
 /****************************************************************************
@@ -250,7 +280,13 @@ int host_ioctl(int fd, int request, unsigned long arg)
 {
   /* Just call the ioctl routine */
 
-  return host_uninterruptible_errno(ioctl, fd, request, arg);
+  int ret = ioctl(fd, request, arg);
+  if (ret < 0)
+    {
+      ret = host_errno_convert(-errno);
+    }
+
+  return ret;
 }
 
 /****************************************************************************
@@ -270,7 +306,13 @@ void host_sync(int fd)
 
 int host_dup(int fd)
 {
-  return host_uninterruptible_errno(dup, fd);
+  int ret = dup(fd);
+  if (ret < 0)
+    {
+      ret = host_errno_convert(-errno);
+    }
+
+  return ret;
 }
 
 /****************************************************************************
@@ -284,7 +326,11 @@ int host_fstat(int fd, struct nuttx_stat_s *buf)
 
   /* Call the host's stat routine */
 
-  ret = host_uninterruptible_errno(fstat, fd, &hostbuf);
+  ret = fstat(fd, &hostbuf);
+  if (ret < 0)
+    {
+      ret = host_errno_convert(-errno);
+    }
 
   /* Map the return values */
 
@@ -303,19 +349,19 @@ int host_fchstat(int fd, const struct nuttx_stat_s *buf, int flags)
 
   if (flags & NUTTX_CH_STAT_MODE)
     {
-      ret = host_uninterruptible_errno(fchmod, fd, buf->st_mode);
+      ret = fchmod(fd, buf->st_mode);
       if (ret < 0)
         {
-          return ret;
+          return host_errno_convert(-errno);
         }
     }
 
   if (flags & (NUTTX_CH_STAT_UID | NUTTX_CH_STAT_GID))
     {
-      ret = host_uninterruptible_errno(fchown, fd, buf->st_uid, buf->st_gid);
+      ret = fchown(fd, buf->st_uid, buf->st_gid);
       if (ret < 0)
         {
-          return ret;
+          return host_errno_convert(-errno);
         }
     }
 
@@ -343,10 +389,10 @@ int host_fchstat(int fd, const struct nuttx_stat_s *buf, int flags)
           times[1].tv_nsec = UTIME_OMIT;
         }
 
-      ret = host_uninterruptible_errno(futimens, fd, times);
+      ret = futimens(fd, times);
       if (ret < 0)
         {
-          return ret;
+          return host_errno_convert(-errno);
         }
     }
 
@@ -359,7 +405,13 @@ int host_fchstat(int fd, const struct nuttx_stat_s *buf, int flags)
 
 int host_ftruncate(int fd, nuttx_off_t length)
 {
-  return host_uninterruptible_errno(ftruncate, fd, length);
+  int ret = ftruncate(fd, length);
+  if (ret < 0)
+    {
+      ret = host_errno_convert(-errno);
+    }
+
+  return ret;
 }
 
 /****************************************************************************
@@ -449,7 +501,13 @@ void host_rewinddir(void *dirp)
 
 int host_closedir(void *dirp)
 {
-  return host_uninterruptible_errno(closedir, dirp);
+  int ret = closedir(dirp);
+  if (ret < 0)
+    {
+      ret = host_errno_convert(-errno);
+    }
+
+  return ret;
 }
 
 /****************************************************************************
@@ -463,7 +521,11 @@ int host_statfs(const char *path, struct nuttx_statfs_s *buf)
 
   /* Call the host's statfs routine */
 
-  ret = host_uninterruptible_errno(statvfs, path, &hostbuf);
+  ret = statvfs(path, &hostbuf);
+  if (ret < 0)
+    {
+      ret = host_errno_convert(-errno);
+    }
 
   /* Map the struct statfs value */
 
@@ -485,7 +547,13 @@ int host_statfs(const char *path, struct nuttx_statfs_s *buf)
 
 int host_unlink(const char *pathname)
 {
-  return host_uninterruptible_errno(unlink, pathname);
+  int ret = unlink(pathname);
+  if (ret < 0)
+    {
+      ret = host_errno_convert(-errno);
+    }
+
+  return ret;
 }
 
 /****************************************************************************
@@ -496,7 +564,13 @@ int host_mkdir(const char *pathname, int mode)
 {
   /* Just call the host's mkdir routine */
 
-  return host_uninterruptible_errno(mkdir, pathname, mode);
+  int ret = mkdir(pathname, mode);
+  if (ret < 0)
+    {
+      ret = host_errno_convert(-errno);
+    }
+
+  return ret;
 }
 
 /****************************************************************************
@@ -505,7 +579,13 @@ int host_mkdir(const char *pathname, int mode)
 
 int host_rmdir(const char *pathname)
 {
-  return host_uninterruptible_errno(rmdir, pathname);
+  int ret = rmdir(pathname);
+  if (ret < 0)
+    {
+      ret = host_errno_convert(-errno);
+    }
+
+  return ret;
 }
 
 /****************************************************************************
@@ -514,7 +594,13 @@ int host_rmdir(const char *pathname)
 
 int host_rename(const char *oldpath, const char *newpath)
 {
-  return host_uninterruptible_errno(rename, oldpath, newpath);
+  int ret = rename(oldpath, newpath);
+  if (ret < 0)
+    {
+      ret = host_errno_convert(-errno);
+    }
+
+  return ret;
 }
 
 /****************************************************************************
@@ -528,7 +614,11 @@ int host_stat(const char *path, struct nuttx_stat_s *buf)
 
   /* Call the host's stat routine */
 
-  ret = host_uninterruptible_errno(stat, path, &hostbuf);
+  ret = stat(path, &hostbuf);
+  if (ret < 0)
+    {
+      ret = host_errno_convert(-errno);
+    }
 
   /* Map the return values */
 
@@ -547,20 +637,19 @@ int host_chstat(const char *path, const struct nuttx_stat_s *buf, int flags)
 
   if (flags & NUTTX_CH_STAT_MODE)
     {
-      ret = host_uninterruptible_errno(chmod, path, buf->st_mode);
+      ret = chmod(path, buf->st_mode);
       if (ret < 0)
         {
-          return ret;
+          return host_errno_convert(-errno);
         }
     }
 
   if (flags & (NUTTX_CH_STAT_UID | NUTTX_CH_STAT_GID))
     {
-      ret = host_uninterruptible_errno(chown, path,
-                                       buf->st_uid, buf->st_gid);
+      ret = chown(path, buf->st_uid, buf->st_gid);
       if (ret < 0)
         {
-          return ret;
+          return host_errno_convert(-errno);
         }
     }
 
@@ -588,10 +677,10 @@ int host_chstat(const char *path, const struct nuttx_stat_s *buf, int flags)
           times[1].tv_nsec = UTIME_OMIT;
         }
 
-      ret = host_uninterruptible_errno(utimensat, AT_FDCWD, path, times, 0);
+      ret = utimensat(AT_FDCWD, path, times, 0);
       if (ret < 0)
         {
-          return ret;
+          return host_errno_convert(-errno);
         }
     }
 
diff --git a/arch/sim/src/sim/posix/sim_hostmisc.c b/arch/sim/src/sim/posix/sim_hostmisc.c
index 6015af0701e..d759f1f57cc 100644
--- a/arch/sim/src/sim/posix/sim_hostmisc.c
+++ b/arch/sim/src/sim/posix/sim_hostmisc.c
@@ -128,38 +128,32 @@ int host_system(char *buf, size_t len, const char *fmt, ...)
   int ret;
   char cmd[512];
   va_list vars;
-  uint64_t flags;
 
   va_start(vars, fmt);
-  ret = host_uninterruptible_errno(vsnprintf, cmd, sizeof(cmd), fmt, vars);
+  ret = vsnprintf(cmd, sizeof(cmd), fmt, vars);
   va_end(vars);
   if (ret <= 0 || ret > sizeof(cmd))
     {
-      return ret < 0 ? ret : -EINVAL;
+      return ret < 0 ? -errno : -EINVAL;
     }
 
   if (buf == NULL)
     {
-      ret = host_uninterruptible_errno(system, cmd);
+      ret = host_uninterruptible(system, cmd);
     }
   else
     {
-      flags = up_irq_save();
       fp = host_uninterruptible(popen, cmd, "r");
       if (fp == NULL)
         {
-          ret = -errno;
-          up_irq_restore(flags);
-          return ret;
+          return -errno;
         }
 
-      up_irq_restore(flags);
-
-      ret = host_uninterruptible_errno(fread, buf, 1, len, fp);
+      ret = host_uninterruptible(fread, buf, 1, len, fp);
       host_uninterruptible(pclose, fp);
     }
 
-  return ret;
+  return ret < 0 ? -errno : ret;
 }
 
 /****************************************************************************
@@ -229,6 +223,6 @@ int host_waitpid(pid_t pid)
 {
   int status;
 
-  pid = host_uninterruptible_errno(waitpid, pid, &status, 0);
-  return pid < 0 ? pid : status;
+  pid = host_uninterruptible(waitpid, pid, &status, 0);
+  return pid < 0 ? -errno : status;
 }
diff --git a/arch/sim/src/sim/posix/sim_hostuart.c b/arch/sim/src/sim/posix/sim_hostuart.c
index 12f1965895e..facc21e467e 100644
--- a/arch/sim/src/sim/posix/sim_hostuart.c
+++ b/arch/sim/src/sim/posix/sim_hostuart.c
@@ -96,15 +96,15 @@ void host_uart_start(void)
 {
   /* Get the current stdin terminal mode */
 
-  host_uninterruptible_no_return(tcgetattr, 0, &g_cooked);
+  tcgetattr(0, &g_cooked);
 
   /* Put stdin into raw mode */
 
-  host_uninterruptible_no_return(setrawmode, 0);
+  setrawmode(0);
 
   /* Restore the original terminal mode before exit */
 
-  host_uninterruptible_no_return(atexit, restoremode);
+  atexit(restoremode);
 }
 
 /****************************************************************************
@@ -115,12 +115,16 @@ int host_uart_open(const char *pathname)
 {
   int fd;
 
-  fd = host_uninterruptible_errno(open, pathname, O_RDWR | O_NONBLOCK);
+  fd = open(pathname, O_RDWR | O_NONBLOCK);
   if (fd >= 0)
     {
       /* keep raw mode */
 
-      host_uninterruptible_no_return(setrawmode, fd);
+      setrawmode(fd);
+    }
+  else
+    {
+      fd = -errno;
     }
 
   return fd;
@@ -132,7 +136,7 @@ int host_uart_open(const char *pathname)
 
 void host_uart_close(int fd)
 {
-  host_uninterruptible(close, fd);
+  close(fd);
 }
 
 /****************************************************************************
@@ -145,11 +149,11 @@ int host_uart_puts(int fd, const char *buf, size_t size)
 
   do
     {
-      ret = host_uninterruptible_errno(write, fd, buf, size);
+      ret = write(fd, buf, size);
     }
-  while (ret < 0 && ret == -EINTR);
+  while (ret < 0 && errno == EINTR);
 
-  return ret;
+  return ret < 0 ? -errno : ret;
 }
 
 /****************************************************************************
@@ -162,11 +166,11 @@ int host_uart_gets(int fd, char *buf, size_t size)
 
   do
     {
-      ret = host_uninterruptible_errno(read, fd, buf, size);
+      ret = read(fd, buf, size);
     }
-  while (ret < 0 && ret == -EINTR);
+  while (ret < 0 && errno == EINTR);
 
-  return ret;
+  return ret < 0 ? -errno : ret;
 }
 
 /****************************************************************************
@@ -178,8 +182,12 @@ int host_uart_getcflag(int fd, unsigned int *cflag)
   struct termios t;
   int ret;
 
-  ret = host_uninterruptible_errno(tcgetattr, fd, &t);
-  if (ret >= 0)
+  ret = tcgetattr(fd, &t);
+  if (ret < 0)
+    {
+      ret = -errno;
+    }
+  else
     {
       *cflag = t.c_cflag;
     }
@@ -196,11 +204,16 @@ int host_uart_setcflag(int fd, unsigned int cflag)
   struct termios t;
   int ret;
 
-  ret = host_uninterruptible_errno(tcgetattr, fd, &t);
+  ret = tcgetattr(fd, &t);
   if (!ret)
     {
       t.c_cflag = cflag;
-      ret = host_uninterruptible_errno(tcsetattr, fd, TCSANOW, &t);
+      ret = tcsetattr(fd, TCSANOW, &t);
+    }
+
+  if (ret < 0)
+    {
+      ret = -errno;
     }
 
   return ret;
@@ -216,7 +229,7 @@ bool host_uart_checkin(int fd)
 
   pfd.fd     = fd;
   pfd.events = POLLIN;
-  return host_uninterruptible(poll, &pfd, 1, 0) == 1;
+  return poll(&pfd, 1, 0) == 1;
 }
 
 /****************************************************************************
@@ -229,7 +242,7 @@ bool host_uart_checkout(int fd)
 
   pfd.fd     = fd;
   pfd.events = POLLOUT;
-  return host_uninterruptible(poll, &pfd, 1, 0) == 1;
+  return poll(&pfd, 1, 0) == 1;
 }
 
 /****************************************************************************
diff --git a/arch/sim/src/sim/sim_internal.h b/arch/sim/src/sim/sim_internal.h
index 68247ebb7da..b3675bb79b7 100644
--- a/arch/sim/src/sim/sim_internal.h
+++ b/arch/sim/src/sim/sim_internal.h
@@ -155,18 +155,6 @@
       }                                                         \
     while (0)
 
-#define host_uninterruptible_errno(func, ...)                   \
-    ({                                                          \
-        uint64_t flags_ = up_irq_save();                        \
-        typeof(func(__VA_ARGS__)) ret_ = func(__VA_ARGS__);     \
-        if (ret_ < 0)                                           \
-          {                                                     \
-            ret_ = host_errno_convert(-errno);                  \
-          }                                                     \
-        up_irq_restore(flags_);                                 \
-        ret_;                                                   \
-    })
-
 /* File System Definitions **************************************************/
 
 /* These definitions characterize the compressed filesystem image */