diff --git a/configs/b-l475e-iot01a/spirit-6lowpan/defconfig b/configs/b-l475e-iot01a/spirit-6lowpan/defconfig
index f155d83a389..54a4f4039de 100644
--- a/configs/b-l475e-iot01a/spirit-6lowpan/defconfig
+++ b/configs/b-l475e-iot01a/spirit-6lowpan/defconfig
@@ -43,7 +43,6 @@ CONFIG_LIBM=y
 CONFIG_MAX_TASKS=16
 CONFIG_MAX_WDOGPARMS=2
 CONFIG_MM_REGIONS=2
-CONFIG_NET_6LOWPAN_FRAMELEN=94
 CONFIG_NET_6LOWPAN=y
 CONFIG_NET_BROADCAST=y
 CONFIG_NET_HOSTNAME="B-L475E-IOT01A"
diff --git a/configs/b-l475e-iot01a/spirit-starhub/defconfig b/configs/b-l475e-iot01a/spirit-starhub/defconfig
index 13cc3d26610..4ac0045dcd6 100644
--- a/configs/b-l475e-iot01a/spirit-starhub/defconfig
+++ b/configs/b-l475e-iot01a/spirit-starhub/defconfig
@@ -32,7 +32,6 @@ CONFIG_LIBM=y
 CONFIG_MAX_TASKS=16
 CONFIG_MAX_WDOGPARMS=2
 CONFIG_MM_REGIONS=2
-CONFIG_NET_6LOWPAN_FRAMELEN=94
 CONFIG_NET_6LOWPAN=y
 CONFIG_NET_BROADCAST=y
 CONFIG_NET_HOSTNAME="B-L475E-IOT01A"
diff --git a/configs/b-l475e-iot01a/spirit-starpoint/defconfig b/configs/b-l475e-iot01a/spirit-starpoint/defconfig
index 5f067557dad..0d04285c956 100644
--- a/configs/b-l475e-iot01a/spirit-starpoint/defconfig
+++ b/configs/b-l475e-iot01a/spirit-starpoint/defconfig
@@ -44,7 +44,6 @@ CONFIG_LIBM=y
 CONFIG_MAX_TASKS=16
 CONFIG_MAX_WDOGPARMS=2
 CONFIG_MM_REGIONS=2
-CONFIG_NET_6LOWPAN_FRAMELEN=94
 CONFIG_NET_6LOWPAN=y
 CONFIG_NET_BROADCAST=y
 CONFIG_NET_HOSTNAME="B-L475E-IOT01A"
diff --git a/net/ieee802154/ieee802154.h b/net/ieee802154/ieee802154.h
index 4f317baa5bf..b2c19acfc5e 100644
--- a/net/ieee802154/ieee802154.h
+++ b/net/ieee802154/ieee802154.h
@@ -76,13 +76,9 @@
 
 #define IEEE802154_MAC_FCSSIZE  2
 
-/* This, then, is the usable size of the frame...
- * REVISIT: Too many frame length definitions
- */
+/* This, then, is the usable size of the frame... */
 
-#if defined(CONFIG_NET_6LOWPAN_FRAMELEN)
-#  define IEEE802_MAX_FRAMELEN CONFIG_NET_6LOWPAN_FRAMELEN
-#elif defined(CONFIG_NET_IEEE802154_FRAMELEN)
+#if defined(CONFIG_NET_IEEE802154_FRAMELEN)
 #  define IEEE802_MAX_FRAMELEN CONFIG_NET_IEEE802154_FRAMELEN
 #else
 #  define IEEE802_MAX_FRAMELEN IEEE802154_MAC_STDFRAME
diff --git a/net/sixlowpan/Kconfig b/net/sixlowpan/Kconfig
index 8722f27a8c1..70620532a5b 100644
--- a/net/sixlowpan/Kconfig
+++ b/net/sixlowpan/Kconfig
@@ -37,15 +37,6 @@ config NET_6LOWPAN_REASS_STATIC
 		buffers.  In that case, only static reassembly buffers are available;
 		when those are exhausted, frames that require reassembly will be lost.
 
-config NET_6LOWPAN_FRAMELEN
-	int "Max Radio Frame Size"
-	default 127
-	range 1 999999
-	---help---
-		Wireless devices use a variety of frame sizes.  For IEEE 802.15.4
-		radios, this should be 127 bytes.  However, some IEEE 802.15.4
-		radios may support non-standard frame lengths.
-
 choice
 	prompt "6LoWPAN Compression"
 	default NET_6LOWPAN_COMPRESSION_HC06
diff --git a/net/sixlowpan/README.txt b/net/sixlowpan/README.txt
index 7de217530b1..60939d5fd17 100644
--- a/net/sixlowpan/README.txt
+++ b/net/sixlowpan/README.txt
@@ -93,9 +93,9 @@ Optimal 6LoWPAN Configuration
 4. To be compressable, port numbers must be in the range 0xf0b0-0xf0bf,
    hexadecimal.  That is 61616-61631 decimal.
 
-5. IOBs: Must be big enough to hold one IEEE802.15.4 frame (CONFIG_NET_6LOWPAN_FRAMELEN,
-   typically 127).  There must be enough IOBs to decompose the largest IPv6
-   packet (CONFIG_NET_6LOWPAN_MTU, default 1294, plus per frame overhead).
+5. IOBs: Must be big enough to hold one IEEE802.15.4 frame (typically 127).
+   There must be enough IOBs to decompose the largest IPv6 packet
+   (CONFIG_NET_6LOWPAN_MTU, default 1294, plus per frame overhead).
 
 Fragmentation Headers
 ---------------------
diff --git a/net/sixlowpan/sixlowpan_framelist.c b/net/sixlowpan/sixlowpan_framelist.c
index 93edda8ccac..545bea004a4 100644
--- a/net/sixlowpan/sixlowpan_framelist.c
+++ b/net/sixlowpan/sixlowpan_framelist.c
@@ -69,24 +69,17 @@
 
 /* Configuration ************************************************************/
 
-/* A single IOB must be big enough to hold a full frame */
-
-#if CONFIG_IOB_BUFSIZE < CONFIG_NET_6LOWPAN_FRAMELEN
-#  error IOBs must be large enough to hold full IEEE802.14.5 frame
-#endif
-
-/* A IOB must also be big enought to hold the maximum MAC header (25 bytes?)
- * plus the FCS and have some amount of space left for the payload.
+/* A single IOB must be big enough to hold a full frame.  This we have to
+ * check at run time.  A IOB must also be big enough to hold the maximum MAC
+ * header (25 bytes?) plus the FCS and have some amount of space left for
+ * the payload.
  */
 
-#if CONFIG_NET_6LOWPAN_FRAMELEN < (SIXLOWPAN_MAC_FCSSIZE + 25)
-#  error CONFIG_NET_6LOWPAN_FRAMELEN too small to hold a IEEE802.14.5 frame
+#define MAX_MACHDR 25 /* REVISIT: This is IEEE 802.15.4 specific */
+#if CONFIG_IOB_BUFSIZE < (SIXLOWPAN_MAC_FCSSIZE + MAX_MACHDR)
+#  error CONFIG_IOB_BUFSIZE too small to hold a IEEE802.14.5 frame
 #endif
 
-/* We must reserve space at the end of the frame for a 2-byte FCS */
-
-#define SIXLOWPAN_FRAMELEN (CONFIG_NET_6LOWPAN_FRAMELEN - SIXLOWPAN_MAC_FCSSIZE)
-
 /* There must be at least enough IOBs to hold the full MTU.  Probably still
  * won't work unless there are a few more.
  */
@@ -385,6 +378,7 @@ int sixlowpan_queue_frames(FAR struct radio_driver_s *radio,
   FAR uint8_t *fptr;
   int framer_hdrlen;
   struct netdev_varaddr_s bcastmac;
+  uint16_t framelen;
   uint16_t pktlen;
   uint16_t paysize;
   uint16_t outlen = 0;
@@ -495,9 +489,40 @@ int sixlowpan_queue_frames(FAR struct radio_driver_s *radio,
 
   ninfo("Header of length=%u protosize=%u\n", g_frame_hdrlen, protosize);
 
-  /* Check if we need to fragment the packet into several frames */
+  /* Get the maximum packet size supported by this radio. */
 
-  if (buflen > (SIXLOWPAN_FRAMELEN - g_frame_hdrlen - protosize))
+  ret = sixlowpan_radio_framelen(radio);
+  if (ret < 0)
+    {
+       nerr("ERROR: sixlowpan_radio_framelen() failed: %d\n", ret);
+       return ret;
+    }
+
+  /* Limit to the maximum size supported by the IOBs */
+
+  if (ret > CONFIG_IOB_BUFSIZE)
+    {
+      ret = CONFIG_IOB_BUFSIZE;
+    }
+
+  /* Reserve space at the end for any FCS that the hardware may include
+   * in the payload.
+   */
+
+  ret -= SIXLOWPAN_MAC_FCSSIZE;
+  if (ret < MAX_MACHDR || ret > UINT16_MAX)
+    {
+       nerr("ERROR: Invalid frame size: %d\n", ret);
+       return ret;
+    }
+
+  framelen = (uint16_t)ret;
+
+  /* Check if we need to fragment the packet into several frames.
+   * We may need to reserve space at the end of the frame for a 2-byte FCS
+   */
+
+  if (buflen > (framelen - g_frame_hdrlen - protosize))
     {
       /* qhead will hold the generated frame list; frames will be
        * added at qtail.
@@ -570,7 +595,7 @@ int sixlowpan_queue_frames(FAR struct radio_driver_s *radio,
        * bytes.
        */
 
-      paysize = (SIXLOWPAN_FRAMELEN - g_frame_hdrlen) & ~7;
+      paysize = (framelen - g_frame_hdrlen) & ~7;
       memcpy(fptr + g_frame_hdrlen + protosize, buf, paysize - protosize);
 
       /* Set outlen to what we already sent from the IP payload */
@@ -642,8 +667,7 @@ int sixlowpan_queue_frames(FAR struct radio_driver_s *radio,
           /* Copy payload and enqueue */
           /* Check for the last fragment */
 
-          paysize = (SIXLOWPAN_FRAMELEN - fragn_hdrlen) &
-                    SIXLOWPAN_DISPATCH_FRAG_MASK;
+          paysize = (framelen - fragn_hdrlen) & SIXLOWPAN_DISPATCH_FRAG_MASK;
           if (paysize > buflen - outlen + protosize)
             {
               /* Last fragment, truncate to the correct length */
diff --git a/wireless/ieee802154/mac802154_loopback.c b/wireless/ieee802154/mac802154_loopback.c
index 3e08f4a8234..1eabcd1a786 100644
--- a/wireless/ieee802154/mac802154_loopback.c
+++ b/wireless/ieee802154/mac802154_loopback.c
@@ -89,13 +89,9 @@
 #  define LO_ADDRSIZE IEEE802154_SADDRSIZE
 #endif
 
-/* Frame size
- * REVISIT: Too many frame length definitions
- */
+/* Frame size */
 
-#if defined(CONFIG_NET_6LOWPAN_FRAMELEN)
-#  define LO_FRAMELEN CONFIG_NET_6LOWPAN_FRAMELEN
-#elif defined(CONFIG_NET_IEEE802154_FRAMELEN)
+#if defined(CONFIG_NET_IEEE802154_FRAMELEN)
 #  define LO_FRAMELEN CONFIG_NET_IEEE802154_FRAMELEN
 #else
 #  define LO_FRAMELEN IEEE802154_MAX_PHY_PACKET_SIZE
diff --git a/wireless/ieee802154/mac802154_netdev.c b/wireless/ieee802154/mac802154_netdev.c
index 6a5bc54d585..4d7f2a9c001 100644
--- a/wireless/ieee802154/mac802154_netdev.c
+++ b/wireless/ieee802154/mac802154_netdev.c
@@ -105,13 +105,9 @@
 #  define MACNET_ADDRSIZE IEEE802154_SADDRSIZE
 #endif
 
-/* Frame size
- * REVISIT: Too many frame length definitions
- */
+/* Frame size */
 
-#if defined(CONFIG_NET_6LOWPAN_FRAMELEN)
-#  define MACNET_FRAMELEN CONFIG_NET_6LOWPAN_FRAMELEN
-#elif defined(CONFIG_NET_IEEE802154_FRAMELEN)
+#if defined(CONFIG_NET_IEEE802154_FRAMELEN)
 #  define MACNET_FRAMELEN CONFIG_NET_IEEE802154_FRAMELEN
 #else
 #  define MACNET_FRAMELEN IEEE802154_MAX_PHY_PACKET_SIZE
diff --git a/wireless/pktradio/pktradio_loopback.c b/wireless/pktradio/pktradio_loopback.c
index ca89e6ef494..c9e144eb4d7 100644
--- a/wireless/pktradio/pktradio_loopback.c
+++ b/wireless/pktradio/pktradio_loopback.c
@@ -97,7 +97,7 @@
 
 /* Fake value for MAC header length */
 
-#if CONFIG_NET_6LOWPAN_FRAMELEN > 40
+#if CONFIG_IOB_BUFSIZE > 40
 #  define MAC_HDRLEN   4
 #else
 #  define MAC_HDRLEN   0
@@ -961,8 +961,8 @@ static int lo_properties(FAR struct radio_driver_s *netdev,
 
   /* General */
 
-  properties->sp_addrlen  = CONFIG_PKTRADIO_ADDRLEN;     /* Length of an address */
-  properties->sp_framelen = CONFIG_NET_6LOWPAN_FRAMELEN; /* Fixed frame length */
+  properties->sp_addrlen  = CONFIG_PKTRADIO_ADDRLEN; /* Length of an address */
+  properties->sp_framelen = CONFIG_IOB_BUFSIZE;      /* Fixed frame length */
 
   /* Multicast address */