diff --git a/arch/arm/src/nrf52/hardware/nrf52_utils.h b/arch/arm/src/nrf52/hardware/nrf52_utils.h
index dc0910e168d..4ecbc1ce7df 100644
--- a/arch/arm/src/nrf52/hardware/nrf52_utils.h
+++ b/arch/arm/src/nrf52/hardware/nrf52_utils.h
@@ -42,6 +42,16 @@
 
 void nrf52_clrpend(int irq);
 
+/****************************************************************************
+ * Name: nrf52_easydma_valid
+ *
+ * Description:
+ *   Validate if easyDMA transfer is possible.
+ *
+ ****************************************************************************/
+
+bool nrf52_easydma_valid(uint32_t addr);
+
 /****************************************************************************
  * Name: nrf52832_errdata_init
  *
diff --git a/arch/arm/src/nrf52/nrf52_adc.c b/arch/arm/src/nrf52/nrf52_adc.c
index 451976f7607..fe276d18ced 100644
--- a/arch/arm/src/nrf52/nrf52_adc.c
+++ b/arch/arm/src/nrf52/nrf52_adc.c
@@ -40,6 +40,7 @@
 #include "nrf52_adc.h"
 
 #include "hardware/nrf52_saadc.h"
+#include "hardware/nrf52_utils.h"
 
 /****************************************************************************
  * Pre-processor Definitions
@@ -262,6 +263,7 @@ static int nrf52_adc_configure(struct nrf52_adc_s *priv)
   /* Configure ADC buffer */
 
   regval = (uint32_t)&priv->buffer;
+  DEBUGASSERT(nrf52_easydma_valid(regval));
   nrf52_adc_putreg(priv, NRF52_SAADC_PTR_OFFSET, regval);
 
   regval = priv->chan_len;
diff --git a/arch/arm/src/nrf52/nrf52_i2c.c b/arch/arm/src/nrf52/nrf52_i2c.c
index b26938556b6..f043c0b785a 100644
--- a/arch/arm/src/nrf52/nrf52_i2c.c
+++ b/arch/arm/src/nrf52/nrf52_i2c.c
@@ -39,6 +39,7 @@
 #include "nrf52_i2c.h"
 
 #include "hardware/nrf52_twi.h"
+#include "hardware/nrf52_utils.h"
 
 /****************************************************************************
  * Pre-processor Definitions
@@ -366,6 +367,7 @@ static int nrf52_i2c_transfer(struct i2c_master_s *dev,
           /* Write TXD data pointer */
 
           regval = (uint32_t)priv->ptr;
+          DEBUGASSERT(nrf52_easydma_valid(regval));
           nrf52_i2c_putreg(priv, NRF52_TWIM_TXDPTR_OFFSET, regval);
 
           /* Write number of bytes in TXD buffer */
@@ -419,6 +421,7 @@ static int nrf52_i2c_transfer(struct i2c_master_s *dev,
           /* Write RXD data pointer */
 
           regval = (uint32_t)priv->ptr;
+          DEBUGASSERT(nrf52_easydma_valid(regval));
           nrf52_i2c_putreg(priv, NRF52_TWIM_RXDPTR_OFFSET, regval);
 
           /* Write number of bytes in RXD buffer */
diff --git a/arch/arm/src/nrf52/nrf52_pwm.c b/arch/arm/src/nrf52/nrf52_pwm.c
index cf6194960aa..634fa9687ad 100644
--- a/arch/arm/src/nrf52/nrf52_pwm.c
+++ b/arch/arm/src/nrf52/nrf52_pwm.c
@@ -38,6 +38,7 @@
 #include "nrf52_pwm.h"
 
 #include "hardware/nrf52_pwm.h"
+#include "hardware/nrf52_utils.h"
 
 /****************************************************************************
  * Pre-processor Definitions
@@ -271,6 +272,7 @@ static int nrf52_pwm_configure(struct nrf52_pwm_s *priv)
   /* Configure sequence 0 */
 
   regval = (uint32_t)priv->seq0;
+  DEBUGASSERT(nrf52_easydma_valid(regval));
   nrf52_pwm_putreg(priv, NRF52_PWM_SEQ0PTR_OFFSET, regval);
 
   regval = PWM_SEQ0_LEN;
diff --git a/arch/arm/src/nrf52/nrf52_radio.c b/arch/arm/src/nrf52/nrf52_radio.c
index 1a01ea69df3..60ba3f1a071 100644
--- a/arch/arm/src/nrf52/nrf52_radio.c
+++ b/arch/arm/src/nrf52/nrf52_radio.c
@@ -39,6 +39,7 @@
 #include "nrf52_radio.h"
 
 #include "hardware/nrf52_radio.h"
+#include "hardware/nrf52_utils.h"
 
 #warning NRF52 RADIO support is EXPERIMENTAL!
 
@@ -748,6 +749,7 @@ static int nrf52_radio_write(struct nrf52_radio_dev_s *dev,
 
   /* Set packet pointer */
 
+  DEBUGASSERT(nrf52_easydma_valid(&dev->txbuf));
   nrf52_radio_putreg(dev, NRF52_RADIO_PACKETPTR_OFFSET, &dev->txbuf);
 
   /* Set state to TX */
@@ -803,6 +805,7 @@ static int nrf52_radio_read(struct nrf52_radio_dev_s *dev,
 
   /* Set packet pointer */
 
+  DEBUGASSERT(nrf52_easydma_valid(&dev->rxbuf));
   nrf52_radio_putreg(dev, NRF52_RADIO_PACKETPTR_OFFSET, &dev->rxbuf);
 
   /* Set state to RX */
diff --git a/arch/arm/src/nrf52/nrf52_spi.c b/arch/arm/src/nrf52/nrf52_spi.c
index f0ce10753aa..f55e6839286 100644
--- a/arch/arm/src/nrf52/nrf52_spi.c
+++ b/arch/arm/src/nrf52/nrf52_spi.c
@@ -42,6 +42,7 @@
 #include "nrf52_spi.h"
 
 #include "hardware/nrf52_spi.h"
+#include "hardware/nrf52_utils.h"
 
 #ifdef CONFIG_NRF52_SPI_MASTER_WORKAROUND_1BYTE_TRANSFER
 #  include "hardware/nrf52_gpiote.h"
@@ -1089,6 +1090,7 @@ static void nrf52_spi_exchange(struct spi_dev_s *dev,
       /* Write RXD data pointer */
 
       regval = (uint32_t)rxbuffer;
+      DEBUGASSERT(nrf52_easydma_valid(regval));
       nrf52_spi_putreg(priv, NRF52_SPIM_RXDPTR_OFFSET, regval);
     }
   else
@@ -1101,6 +1103,7 @@ static void nrf52_spi_exchange(struct spi_dev_s *dev,
       /* Write TXD data pointer */
 
       regval = (uint32_t)txbuffer;
+      DEBUGASSERT(nrf52_easydma_valid(regval));
       nrf52_spi_putreg(priv, NRF52_SPIM_TXDPTR_OFFSET, regval);
     }
   else
diff --git a/arch/arm/src/nrf52/nrf52_usbd.c b/arch/arm/src/nrf52/nrf52_usbd.c
index 4ae480b688f..26902a7c982 100644
--- a/arch/arm/src/nrf52/nrf52_usbd.c
+++ b/arch/arm/src/nrf52/nrf52_usbd.c
@@ -49,6 +49,7 @@
 
 #include "hardware/nrf52_usbd.h"
 #include "hardware/nrf52_power.h"
+#include "hardware/nrf52_utils.h"
 
 /****************************************************************************
  * Pre-processor Definitions
@@ -1023,6 +1024,7 @@ static void nrf52_epin_transfer(struct nrf52_ep_s *privep, uint8_t *buf,
     {
       /* Configure EasyDMA */
 
+      DEBUGASSERT(nrf52_easydma_valid((uint32_t)buf));
       nrf52_putreg((uint32_t)buf, NRF52_USBD_EPIN_PTR(privep->epphy));
       nrf52_putreg(nbytes, NRF52_USBD_EPIN_MAXCNT(privep->epphy));
 
@@ -1071,6 +1073,7 @@ static void nrf52_epout_transfer(struct nrf52_ep_s *privep)
 
   /* Configure EasyDMA */
 
+  DEBUGASSERT(nrf52_easydma_valid((uint32_t)privep->rxbuff));
   nrf52_putreg((uint32_t)privep->rxbuff,
                NRF52_USBD_EPOUT_PTR(privep->epphy));
   nrf52_putreg(nbytes, NRF52_USBD_EPOUT_MAXCNT(privep->epphy));
diff --git a/arch/arm/src/nrf52/nrf52_utils.c b/arch/arm/src/nrf52/nrf52_utils.c
index 9c5e762df42..e871019f97a 100644
--- a/arch/arm/src/nrf52/nrf52_utils.c
+++ b/arch/arm/src/nrf52/nrf52_utils.c
@@ -30,6 +30,7 @@
 #include "arm_internal.h"
 #include "nrf52_irq.h"
 #include "hardware/nrf52_utils.h"
+#include "hardware/nrf52_memorymap.h"
 
 /****************************************************************************
  * Public Functions
@@ -65,3 +66,25 @@ void nrf52_clrpend(int irq)
         }
     }
 }
+
+/****************************************************************************
+ * Name: nrf52_easydma_valid
+ *
+ * Description:
+ *   Validate if easyDMA transfer is possible.
+ *
+ ****************************************************************************/
+
+bool nrf52_easydma_valid(uint32_t addr)
+{
+#ifdef CONFIG_DEBUG_FEATURES
+  /* EasyDMA cannot access flash memory */
+
+  if (addr >= NRF52_FLASH_BASE && addr < NRF52_SRAM_BASE)
+    {
+      return false;
+    }
+#endif
+
+  return true;
+}
diff --git a/arch/arm/src/nrf53/hardware/nrf53_utils.h b/arch/arm/src/nrf53/hardware/nrf53_utils.h
index 9a304bad3a9..3fb14a09b6d 100644
--- a/arch/arm/src/nrf53/hardware/nrf53_utils.h
+++ b/arch/arm/src/nrf53/hardware/nrf53_utils.h
@@ -43,15 +43,14 @@
 void nrf53_clrpend(int irq);
 
 /****************************************************************************
- * Name: nrf53832_errdata_init
+ * Name: nrf53_easydma_valid
  *
  * Description:
- *   ErrData correction for 52832
- *   required for most interrupts.
+ *   Validate if easyDMA transfer is possible.
  *
  ****************************************************************************/
 
-void nrf53832_errdata_init(void);
+bool nrf53_easydma_valid(uint32_t addr);
 
 /****************************************************************************
  * Name: nrf53_task_trigger
diff --git a/arch/arm/src/nrf53/nrf53_adc.c b/arch/arm/src/nrf53/nrf53_adc.c
index 83d988229f3..3a87f783ce9 100644
--- a/arch/arm/src/nrf53/nrf53_adc.c
+++ b/arch/arm/src/nrf53/nrf53_adc.c
@@ -40,6 +40,7 @@
 #include "nrf53_adc.h"
 
 #include "hardware/nrf53_saadc.h"
+#include "hardware/nrf53_utils.h"
 
 /****************************************************************************
  * Pre-processor Definitions
@@ -262,6 +263,7 @@ static int nrf53_adc_configure(struct nrf53_adc_s *priv)
   /* Configure ADC buffer */
 
   regval = (uint32_t)&priv->buffer;
+  DEBUGASSERT(nrf53_easydma_valid(regval));
   nrf53_adc_putreg(priv, NRF53_SAADC_PTR_OFFSET, regval);
 
   regval = priv->chan_len;
diff --git a/arch/arm/src/nrf53/nrf53_i2c.c b/arch/arm/src/nrf53/nrf53_i2c.c
index f5f324d835c..7e1628d500f 100644
--- a/arch/arm/src/nrf53/nrf53_i2c.c
+++ b/arch/arm/src/nrf53/nrf53_i2c.c
@@ -39,6 +39,7 @@
 #include "nrf53_i2c.h"
 
 #include "hardware/nrf53_twi.h"
+#include "hardware/nrf53_utils.h"
 
 /****************************************************************************
  * Pre-processor Definitions
@@ -416,6 +417,7 @@ static int nrf53_i2c_transfer(struct i2c_master_s *dev,
           /* Write TXD data pointer */
 
           regval = (uint32_t)priv->ptr;
+          DEBUGASSERT(nrf53_easydma_valid(regval));
           nrf53_i2c_putreg(priv, NRF53_TWIM_TXDPTR_OFFSET, regval);
 
           /* Write number of bytes in TXD buffer */
@@ -469,6 +471,7 @@ static int nrf53_i2c_transfer(struct i2c_master_s *dev,
           /* Write RXD data pointer */
 
           regval = (uint32_t)priv->ptr;
+          DEBUGASSERT(nrf53_easydma_valid(regval));
           nrf53_i2c_putreg(priv, NRF53_TWIM_RXDPTR_OFFSET, regval);
 
           /* Write number of bytes in RXD buffer */
diff --git a/arch/arm/src/nrf53/nrf53_pwm.c b/arch/arm/src/nrf53/nrf53_pwm.c
index b2c40d95274..3186082f823 100644
--- a/arch/arm/src/nrf53/nrf53_pwm.c
+++ b/arch/arm/src/nrf53/nrf53_pwm.c
@@ -38,6 +38,7 @@
 #include "nrf53_pwm.h"
 
 #include "hardware/nrf53_pwm.h"
+#include "hardware/nrf53_utils.h"
 
 /****************************************************************************
  * Pre-processor Definitions
@@ -249,6 +250,7 @@ static int nrf53_pwm_configure(struct nrf53_pwm_s *priv)
   /* Configure sequence 0 */
 
   regval = (uint32_t)priv->seq0;
+  DEBUGASSERT(nrf53_easydma_valid(regval));
   nrf53_pwm_putreg(priv, NRF53_PWM_SEQ0PTR_OFFSET, regval);
 
   regval = PWM_SEQ0_LEN;
diff --git a/arch/arm/src/nrf53/nrf53_spi.c b/arch/arm/src/nrf53/nrf53_spi.c
index 1759835e711..b15bf6306a2 100644
--- a/arch/arm/src/nrf53/nrf53_spi.c
+++ b/arch/arm/src/nrf53/nrf53_spi.c
@@ -42,6 +42,7 @@
 #include "nrf53_spi.h"
 
 #include "hardware/nrf53_spi.h"
+#include "hardware/nrf53_utils.h"
 
 /****************************************************************************
  * Private Types
@@ -1083,6 +1084,7 @@ static void nrf53_spi_exchange(struct spi_dev_s *dev,
       /* Write RXD data pointer */
 
       regval = (uint32_t)rxbuffer;
+      DEBUGASSERT(nrf53_easydma_valid(regval));
       nrf53_spi_putreg(priv, NRF53_SPIM_RXDPTR_OFFSET, regval);
     }
   else
@@ -1095,6 +1097,7 @@ static void nrf53_spi_exchange(struct spi_dev_s *dev,
       /* Write TXD data pointer */
 
       regval = (uint32_t)txbuffer;
+      DEBUGASSERT(nrf53_easydma_valid(regval));
       nrf53_spi_putreg(priv, NRF53_SPIM_TXDPTR_OFFSET, regval);
     }
   else
diff --git a/arch/arm/src/nrf53/nrf53_usbd.c b/arch/arm/src/nrf53/nrf53_usbd.c
index 44760a768f8..ca6d3fc6faf 100644
--- a/arch/arm/src/nrf53/nrf53_usbd.c
+++ b/arch/arm/src/nrf53/nrf53_usbd.c
@@ -49,6 +49,7 @@
 
 #include "hardware/nrf53_usbd.h"
 #include "hardware/nrf53_usbreg.h"
+#include "hardware/nrf53_utils.h"
 
 /****************************************************************************
  * Pre-processor Definitions
@@ -1023,6 +1024,7 @@ static void nrf53_epin_transfer(struct nrf53_ep_s *privep, uint8_t *buf,
     {
       /* Configure EasyDMA */
 
+      DEBUGASSERT(nrf53_easydma_valid((uint32_t)buf));
       nrf53_putreg((uint32_t)buf, NRF53_USBD_EPIN_PTR(privep->epphy));
       nrf53_putreg(nbytes, NRF53_USBD_EPIN_MAXCNT(privep->epphy));
 
@@ -1071,6 +1073,7 @@ static void nrf53_epout_transfer(struct nrf53_ep_s *privep)
 
   /* Configure EasyDMA */
 
+  DEBUGASSERT(nrf53_easydma_valid((uint32_t)privep->rxbuff));
   nrf53_putreg((uint32_t)privep->rxbuff,
                NRF53_USBD_EPOUT_PTR(privep->epphy));
   nrf53_putreg(nbytes, NRF53_USBD_EPOUT_MAXCNT(privep->epphy));
diff --git a/arch/arm/src/nrf53/nrf53_utils.c b/arch/arm/src/nrf53/nrf53_utils.c
index 215b2c0d250..b2f97182e4b 100644
--- a/arch/arm/src/nrf53/nrf53_utils.c
+++ b/arch/arm/src/nrf53/nrf53_utils.c
@@ -30,6 +30,7 @@
 #include "arm_internal.h"
 #include "nrf53_irq.h"
 #include "hardware/nrf53_utils.h"
+#include "hardware/nrf53_memorymap.h"
 
 /****************************************************************************
  * Public Functions
@@ -65,3 +66,25 @@ void nrf53_clrpend(int irq)
         }
     }
 }
+
+/****************************************************************************
+ * Name: nrf53_easydma_valid
+ *
+ * Description:
+ *   Validate if easyDMA transfer is possible.
+ *
+ ****************************************************************************/
+
+bool nrf53_easydma_valid(uint32_t addr)
+{
+#ifdef CONFIG_DEBUG_FEATURES
+  /* EasyDMA cannot access flash memory */
+
+  if (addr >= NRF53_FLASH_BASE && addr < NRF53_SRAM_BASE)
+    {
+      return false;
+    }
+#endif
+
+  return true;
+}