diff --git a/esphome/components/pmsx003/sensor.py b/esphome/components/pmsx003/sensor.py
index cdcedc85acc..0a11120bf03 100644
--- a/esphome/components/pmsx003/sensor.py
+++ b/esphome/components/pmsx003/sensor.py
@@ -185,7 +185,7 @@ def validate_update_interval(value):
     return value
 
 
-CONFIG_SCHEMA = (
+CONFIG_SCHEMA = cv.All(
     cv.Schema(
         {
             cv.GenerateID(): cv.declare_id(PMSX003Component),
@@ -290,7 +290,8 @@ CONFIG_SCHEMA = (
         }
     )
     .extend(cv.COMPONENT_SCHEMA)
-    .extend(uart.UART_DEVICE_SCHEMA)
+    .extend(uart.UART_DEVICE_SCHEMA),
+    validate_pmsx003_sensors,
 )