diff --git a/esphome/components/mcp23016/mcp23016.cpp b/esphome/components/mcp23016/mcp23016.cpp
index 118a77ce378..b7a9cfd0ce7 100644
--- a/esphome/components/mcp23016/mcp23016.cpp
+++ b/esphome/components/mcp23016/mcp23016.cpp
@@ -37,7 +37,10 @@ void IRAM_ATTR MCP23016::gpio_intr(MCP23016 *arg) { arg->enable_loop_soon_any_co
 void MCP23016::loop() {
   // Invalidate cache at the start of each loop
   this->reset_pin_cache_();
-  if (this->interrupt_pin_ != nullptr) {
+  // Only disable the loop once INT has actually gone HIGH. Input transitions that straddle the
+  // I2C read leave INT asserted without re-firing a falling edge, which would strand us with
+  // stale state forever; keep looping until the line is released so we self-heal.
+  if (this->interrupt_pin_ != nullptr && this->interrupt_pin_->digital_read()) {
     this->disable_loop();
   }
 }
diff --git a/esphome/components/mcp23xxx_base/mcp23xxx_base.h b/esphome/components/mcp23xxx_base/mcp23xxx_base.h
index 6efd04e2463..8a87dac1433 100644
--- a/esphome/components/mcp23xxx_base/mcp23xxx_base.h
+++ b/esphome/components/mcp23xxx_base/mcp23xxx_base.h
@@ -21,7 +21,10 @@ template<uint8_t N> class MCP23XXXBase : public Component, public gpio_expander:
 
   void loop() override {
     this->reset_pin_cache_();
-    if (this->interrupt_pin_ != nullptr) {
+    // Only disable the loop once INT has actually gone HIGH. Input transitions that straddle the
+    // I2C read leave INT asserted without re-firing a falling edge, which would strand us with
+    // stale state forever; keep looping until the line is released so we self-heal.
+    if (this->interrupt_pin_ != nullptr && this->interrupt_pin_->digital_read()) {
       this->disable_loop();
     }
   }
diff --git a/esphome/components/pca6416a/pca6416a.cpp b/esphome/components/pca6416a/pca6416a.cpp
index dc7463b01ba..d617336e7e2 100644
--- a/esphome/components/pca6416a/pca6416a.cpp
+++ b/esphome/components/pca6416a/pca6416a.cpp
@@ -62,7 +62,10 @@ void IRAM_ATTR PCA6416AComponent::gpio_intr(PCA6416AComponent *arg) { arg->enabl
 void PCA6416AComponent::loop() {
   // Invalidate cache at the start of each loop
   this->reset_pin_cache_();
-  if (this->interrupt_pin_ != nullptr) {
+  // Only disable the loop once INT has actually gone HIGH. Input transitions that straddle the
+  // I2C read leave INT asserted without re-firing a falling edge, which would strand us with
+  // stale state forever; keep looping until the line is released so we self-heal.
+  if (this->interrupt_pin_ != nullptr && this->interrupt_pin_->digital_read()) {
     this->disable_loop();
   }
 }
diff --git a/esphome/components/pca9554/pca9554.cpp b/esphome/components/pca9554/pca9554.cpp
index ac4f119dfee..393bbfd61ef 100644
--- a/esphome/components/pca9554/pca9554.cpp
+++ b/esphome/components/pca9554/pca9554.cpp
@@ -50,8 +50,10 @@ void IRAM_ATTR PCA9554Component::gpio_intr(PCA9554Component *arg) { arg->enable_
 void PCA9554Component::loop() {
   // Invalidate the cache so the next digital_read() triggers a fresh I2C read
   this->reset_pin_cache_();
-  if (this->interrupt_pin_ != nullptr) {
-    // Interrupt-driven: disable loop until next interrupt fires
+  // Only disable the loop once INT has actually gone HIGH. Input transitions that straddle the
+  // I2C read leave INT asserted without re-firing a falling edge, which would strand us with
+  // stale state forever; keep looping until the line is released so we self-heal.
+  if (this->interrupt_pin_ != nullptr && this->interrupt_pin_->digital_read()) {
     this->disable_loop();
   }
 }
diff --git a/esphome/components/pcf8574/pcf8574.cpp b/esphome/components/pcf8574/pcf8574.cpp
index bf4a9442a26..8fe8526797b 100644
--- a/esphome/components/pcf8574/pcf8574.cpp
+++ b/esphome/components/pcf8574/pcf8574.cpp
@@ -31,8 +31,10 @@ void IRAM_ATTR PCF8574Component::gpio_intr(PCF8574Component *arg) { arg->enable_
 void PCF8574Component::loop() {
   // Invalidate the cache so the next digital_read() triggers a fresh I2C read
   this->reset_pin_cache_();
-  if (this->interrupt_pin_ != nullptr) {
-    // Interrupt-driven: disable loop until next interrupt fires
+  // Only disable the loop once INT has actually gone HIGH. Input transitions that straddle the
+  // I2C read leave INT asserted without re-firing a falling edge, which would strand us with
+  // stale state forever; keep looping until the line is released so we self-heal.
+  if (this->interrupt_pin_ != nullptr && this->interrupt_pin_->digital_read()) {
     this->disable_loop();
   }
 }
diff --git a/esphome/components/pi4ioe5v6408/pi4ioe5v6408.cpp b/esphome/components/pi4ioe5v6408/pi4ioe5v6408.cpp
index 6e8631022a7..00f29983be8 100644
--- a/esphome/components/pi4ioe5v6408/pi4ioe5v6408.cpp
+++ b/esphome/components/pi4ioe5v6408/pi4ioe5v6408.cpp
@@ -82,7 +82,10 @@ void PI4IOE5V6408Component::pin_mode(uint8_t pin, gpio::Flags flags) {
 
 void PI4IOE5V6408Component::loop() {
   this->reset_pin_cache_();
-  if (this->interrupt_pin_ != nullptr) {
+  // Only disable the loop once INT has actually gone HIGH. Input transitions that straddle the
+  // I2C read leave INT asserted without re-firing a falling edge, which would strand us with
+  // stale state forever; keep looping until the line is released so we self-heal.
+  if (this->interrupt_pin_ != nullptr && this->interrupt_pin_->digital_read()) {
     this->disable_loop();
   }
 }
diff --git a/esphome/components/tca9555/tca9555.cpp b/esphome/components/tca9555/tca9555.cpp
index 3eb794df441..2fefe08c0d7 100644
--- a/esphome/components/tca9555/tca9555.cpp
+++ b/esphome/components/tca9555/tca9555.cpp
@@ -57,7 +57,10 @@ void TCA9555Component::pin_mode(uint8_t pin, gpio::Flags flags) {
 }
 void TCA9555Component::loop() {
   this->reset_pin_cache_();
-  if (this->interrupt_pin_ != nullptr) {
+  // Only disable the loop once INT has actually gone HIGH. Input transitions that straddle the
+  // I2C read leave INT asserted without re-firing a falling edge, which would strand us with
+  // stale state forever; keep looping until the line is released so we self-heal.
+  if (this->interrupt_pin_ != nullptr && this->interrupt_pin_->digital_read()) {
     this->disable_loop();
   }
 }