diff --git a/esphome/components/mcp23008/mcp23008.cpp b/esphome/components/mcp23008/mcp23008.cpp
index b7a4276c46..5f73e03f6f 100644
--- a/esphome/components/mcp23008/mcp23008.cpp
+++ b/esphome/components/mcp23008/mcp23008.cpp
@@ -23,11 +23,6 @@ void MCP23008::setup() {
     this->write_reg(mcp23x08_base::MCP23X08_IOCON, iocon | IOCON_ODR);
   }
 
-  // Clear any latched interrupt by reading GPIO before attaching ISR
-  if (this->interrupt_pin_ != nullptr) {
-    uint8_t val;
-    this->read_reg(mcp23x08_base::MCP23X08_GPIO, &val);
-  }
   this->setup_interrupt_pin_();
 }
 
diff --git a/esphome/components/mcp23017/mcp23017.cpp b/esphome/components/mcp23017/mcp23017.cpp
index b1775f2402..212c15ccf2 100644
--- a/esphome/components/mcp23017/mcp23017.cpp
+++ b/esphome/components/mcp23017/mcp23017.cpp
@@ -33,12 +33,6 @@ void MCP23017::setup() {
     this->write_reg(mcp23x17_base::MCP23X17_IOCONB, iocon | iocon_flags);
   }
 
-  // Clear any latched interrupt by reading GPIO before attaching ISR
-  if (this->interrupt_pin_ != nullptr) {
-    uint8_t val;
-    this->read_reg(mcp23x17_base::MCP23X17_GPIOA, &val);
-    this->read_reg(mcp23x17_base::MCP23X17_GPIOB, &val);
-  }
   this->setup_interrupt_pin_();
 }
 
diff --git a/esphome/components/mcp23s08/mcp23s08.cpp b/esphome/components/mcp23s08/mcp23s08.cpp
index 2291381646..983c1aa600 100644
--- a/esphome/components/mcp23s08/mcp23s08.cpp
+++ b/esphome/components/mcp23s08/mcp23s08.cpp
@@ -35,11 +35,6 @@ void MCP23S08::setup() {
     this->write_reg(mcp23x08_base::MCP23X08_IOCON, IOCON_SEQOP | IOCON_HAEN | IOCON_ODR);
   }
 
-  // Clear any latched interrupt by reading GPIO before attaching ISR
-  if (this->interrupt_pin_ != nullptr) {
-    uint8_t val;
-    this->read_reg(mcp23x08_base::MCP23X08_GPIO, &val);
-  }
   this->setup_interrupt_pin_();
 }
 
diff --git a/esphome/components/mcp23s17/mcp23s17.cpp b/esphome/components/mcp23s17/mcp23s17.cpp
index f27b55c6f6..db9a34e230 100644
--- a/esphome/components/mcp23s17/mcp23s17.cpp
+++ b/esphome/components/mcp23s17/mcp23s17.cpp
@@ -51,12 +51,6 @@ void MCP23S17::setup() {
     this->write_reg(mcp23x17_base::MCP23X17_IOCONB, iocon_flags);
   }
 
-  // Clear any latched interrupt by reading GPIO before attaching ISR
-  if (this->interrupt_pin_ != nullptr) {
-    uint8_t val;
-    this->read_reg(mcp23x17_base::MCP23X17_GPIOA, &val);
-    this->read_reg(mcp23x17_base::MCP23X17_GPIOB, &val);
-  }
   this->setup_interrupt_pin_();
 }
 
diff --git a/esphome/components/pi4ioe5v6408/pi4ioe5v6408.cpp b/esphome/components/pi4ioe5v6408/pi4ioe5v6408.cpp
index 610015bbe6..fe1df6cbb0 100644
--- a/esphome/components/pi4ioe5v6408/pi4ioe5v6408.cpp
+++ b/esphome/components/pi4ioe5v6408/pi4ioe5v6408.cpp
@@ -35,9 +35,6 @@ void PI4IOE5V6408Component::setup() {
   }
 
   if (this->interrupt_pin_ != nullptr) {
-    // Clear any latched interrupt status from before boot
-    uint8_t status;
-    this->read_byte(PI4IOE5V6408_REGISTER_INTERRUPT_STATUS, &status);
     this->interrupt_pin_->setup();
     this->interrupt_pin_->attach_interrupt(&PI4IOE5V6408Component::gpio_intr, this, gpio::INTERRUPT_FALLING_EDGE);
     this->set_invalidate_on_read_(false);