diff --git a/esphome/components/pca6416a/__init__.py b/esphome/components/pca6416a/__init__.py
index b6e156e7ff..813bb35c48 100644
--- a/esphome/components/pca6416a/__init__.py
+++ b/esphome/components/pca6416a/__init__.py
@@ -5,6 +5,7 @@ import esphome.config_validation as cv
 from esphome.const import (
     CONF_ID,
     CONF_INPUT,
+    CONF_INTERRUPT_PIN,
     CONF_INVERTED,
     CONF_MODE,
     CONF_NUMBER,
@@ -25,7 +26,12 @@ PCA6416AGPIOPin = pca6416a_ns.class_(
 
 CONF_PCA6416A = "pca6416a"
 CONFIG_SCHEMA = (
-    cv.Schema({cv.Required(CONF_ID): cv.declare_id(PCA6416AComponent)})
+    cv.Schema(
+        {
+            cv.Required(CONF_ID): cv.declare_id(PCA6416AComponent),
+            cv.Optional(CONF_INTERRUPT_PIN): pins.internal_gpio_input_pin_schema,
+        }
+    )
     .extend(cv.COMPONENT_SCHEMA)
     .extend(i2c.i2c_device_schema(0x21))
 )
@@ -35,6 +41,8 @@ async def to_code(config):
     var = cg.new_Pvariable(config[CONF_ID])
     await cg.register_component(var, config)
     await i2c.register_i2c_device(var, config)
+    if interrupt_pin := config.get(CONF_INTERRUPT_PIN):
+        cg.add(var.set_interrupt_pin(await cg.gpio_pin_expression(interrupt_pin)))
 
 
 def validate_mode(value):
diff --git a/esphome/components/pca6416a/pca6416a.cpp b/esphome/components/pca6416a/pca6416a.cpp
index f393af88ce..dc7463b01b 100644
--- a/esphome/components/pca6416a/pca6416a.cpp
+++ b/esphome/components/pca6416a/pca6416a.cpp
@@ -49,11 +49,22 @@ void PCA6416AComponent::setup() {
 
   ESP_LOGD(TAG, "Initialization complete. Warning: %d, Error: %d", this->status_has_warning(),
            this->status_has_error());
+
+  if (this->interrupt_pin_ != nullptr) {
+    this->interrupt_pin_->setup();
+    this->interrupt_pin_->attach_interrupt(&PCA6416AComponent::gpio_intr, this, gpio::INTERRUPT_FALLING_EDGE);
+    this->set_invalidate_on_read_(false);
+  }
+  this->disable_loop();
 }
 
+void IRAM_ATTR PCA6416AComponent::gpio_intr(PCA6416AComponent *arg) { arg->enable_loop_soon_any_context(); }
 void PCA6416AComponent::loop() {
   // Invalidate cache at the start of each loop
   this->reset_pin_cache_();
+  if (this->interrupt_pin_ != nullptr) {
+    this->disable_loop();
+  }
 }
 
 void PCA6416AComponent::dump_config() {
@@ -62,6 +73,7 @@ void PCA6416AComponent::dump_config() {
   } else {
     ESP_LOGCONFIG(TAG, "PCA6416A:");
   }
+  LOG_PIN("  Interrupt Pin: ", this->interrupt_pin_);
   LOG_I2C_DEVICE(this)
   if (this->is_failed()) {
     ESP_LOGE(TAG, ESP_LOG_MSG_COMM_FAIL);
@@ -101,6 +113,9 @@ void PCA6416AComponent::pin_mode(uint8_t pin, gpio::Flags flags) {
       this->update_register_(pin, true, pull_dir);
       this->update_register_(pin, false, pull_en);
     }
+    if (this->interrupt_pin_ == nullptr) {
+      this->enable_loop();
+    }
   } else if (flags == (gpio::FLAG_INPUT | gpio::FLAG_PULLUP)) {
     this->update_register_(pin, true, io_dir);
     if (has_pullup_) {
@@ -109,6 +124,9 @@ void PCA6416AComponent::pin_mode(uint8_t pin, gpio::Flags flags) {
     } else {
       ESP_LOGW(TAG, "Your PCA6416A does not support pull-up resistors");
     }
+    if (this->interrupt_pin_ == nullptr) {
+      this->enable_loop();
+    }
   } else if (flags == gpio::FLAG_OUTPUT) {
     this->update_register_(pin, false, io_dir);
   }
diff --git a/esphome/components/pca6416a/pca6416a.h b/esphome/components/pca6416a/pca6416a.h
index 138a51cc20..4d2e6b219e 100644
--- a/esphome/components/pca6416a/pca6416a.h
+++ b/esphome/components/pca6416a/pca6416a.h
@@ -24,7 +24,10 @@ class PCA6416AComponent : public Component,
 
   void dump_config() override;
 
+  void set_interrupt_pin(InternalGPIOPin *pin) { this->interrupt_pin_ = pin; }
+
  protected:
+  static void IRAM_ATTR gpio_intr(PCA6416AComponent *arg);
   // Virtual methods from CachedGpioExpander
   bool digital_read_hw(uint8_t pin) override;
   bool digital_read_cache(uint8_t pin) override;
@@ -43,6 +46,7 @@ class PCA6416AComponent : public Component,
   esphome::i2c::ErrorCode last_error_;
   /// Only the PCAL6416A has pull-up resistors
   bool has_pullup_{false};
+  InternalGPIOPin *interrupt_pin_{nullptr};
 };
 
 /// Helper class to expose a PCA6416A pin as an internal input GPIO pin.
diff --git a/tests/components/pca6416a/common.yaml b/tests/components/pca6416a/common.yaml
index 9ad6e2fb15..09083c6c15 100644
--- a/tests/components/pca6416a/common.yaml
+++ b/tests/components/pca6416a/common.yaml
@@ -2,6 +2,10 @@ pca6416a:
   - id: pca6416a_hub
     i2c_id: i2c_bus
     address: 0x21
+  - id: pca6416a_hub_int
+    i2c_id: i2c_bus
+    address: 0x22
+    interrupt_pin: ${interrupt_pin}
 
 binary_sensor:
   - platform: gpio
diff --git a/tests/components/pca6416a/test.esp32-idf.yaml b/tests/components/pca6416a/test.esp32-idf.yaml
index b47e39c389..8c3b341dce 100644
--- a/tests/components/pca6416a/test.esp32-idf.yaml
+++ b/tests/components/pca6416a/test.esp32-idf.yaml
@@ -1,3 +1,6 @@
+substitutions:
+  interrupt_pin: GPIO15
+
 packages:
   i2c: !include ../../test_build_components/common/i2c/esp32-idf.yaml
 
diff --git a/tests/components/pca6416a/test.esp8266-ard.yaml b/tests/components/pca6416a/test.esp8266-ard.yaml
index 4a98b9388a..69b243bfd8 100644
--- a/tests/components/pca6416a/test.esp8266-ard.yaml
+++ b/tests/components/pca6416a/test.esp8266-ard.yaml
@@ -1,3 +1,6 @@
+substitutions:
+  interrupt_pin: GPIO15
+
 packages:
   i2c: !include ../../test_build_components/common/i2c/esp8266-ard.yaml
 
diff --git a/tests/components/pca6416a/test.rp2040-ard.yaml b/tests/components/pca6416a/test.rp2040-ard.yaml
index 319a7c71a6..b8ad1e4792 100644
--- a/tests/components/pca6416a/test.rp2040-ard.yaml
+++ b/tests/components/pca6416a/test.rp2040-ard.yaml
@@ -1,3 +1,6 @@
+substitutions:
+  interrupt_pin: GPIO2
+
 packages:
   i2c: !include ../../test_build_components/common/i2c/rp2040-ard.yaml