diff --git a/esphome/components/mcp23008/mcp23008.cpp b/esphome/components/mcp23008/mcp23008.cpp
index 64b120daa49..c3c82f36483 100644
--- a/esphome/components/mcp23008/mcp23008.cpp
+++ b/esphome/components/mcp23008/mcp23008.cpp
@@ -22,6 +22,8 @@ void MCP23008::setup() {
     // enable open-drain interrupt pins, 3.3V-safe
     this->write_reg(mcp23x08_base::MCP23X08_IOCON, iocon | IOCON_ODR);
   }
+
+  this->setup_interrupt_pin_();
 }
 
 void MCP23008::dump_config() { ESP_LOGCONFIG(TAG, "MCP23008:"); }
diff --git a/esphome/components/mcp23017/mcp23017.cpp b/esphome/components/mcp23017/mcp23017.cpp
index e14e317d440..556ef96ac5e 100644
--- a/esphome/components/mcp23017/mcp23017.cpp
+++ b/esphome/components/mcp23017/mcp23017.cpp
@@ -24,6 +24,8 @@ void MCP23017::setup() {
     this->write_reg(mcp23x17_base::MCP23X17_IOCONA, iocon | IOCON_ODR);
     this->write_reg(mcp23x17_base::MCP23X17_IOCONB, iocon | IOCON_ODR);
   }
+
+  this->setup_interrupt_pin_();
 }
 
 void MCP23017::dump_config() { ESP_LOGCONFIG(TAG, "MCP23017:"); }
diff --git a/esphome/components/mcp23s08/mcp23s08.cpp b/esphome/components/mcp23s08/mcp23s08.cpp
index 1c17b66637f..514d7c8db35 100644
--- a/esphome/components/mcp23s08/mcp23s08.cpp
+++ b/esphome/components/mcp23s08/mcp23s08.cpp
@@ -34,6 +34,8 @@ void MCP23S08::setup() {
     // enable open-drain interrupt pins, 3.3V-safe (addressed, only this chip)
     this->write_reg(mcp23x08_base::MCP23X08_IOCON, IOCON_SEQOP | IOCON_HAEN | IOCON_ODR);
   }
+
+  this->setup_interrupt_pin_();
 }
 
 void MCP23S08::dump_config() {
diff --git a/esphome/components/mcp23s17/mcp23s17.cpp b/esphome/components/mcp23s17/mcp23s17.cpp
index c6abd7ad594..be775bc7c99 100644
--- a/esphome/components/mcp23s17/mcp23s17.cpp
+++ b/esphome/components/mcp23s17/mcp23s17.cpp
@@ -42,6 +42,8 @@ void MCP23S17::setup() {
     this->write_reg(mcp23x17_base::MCP23X17_IOCONA, IOCON_SEQOP | IOCON_HAEN | IOCON_ODR);
     this->write_reg(mcp23x17_base::MCP23X17_IOCONB, IOCON_SEQOP | IOCON_HAEN | IOCON_ODR);
   }
+
+  this->setup_interrupt_pin_();
 }
 
 void MCP23S17::dump_config() {
diff --git a/esphome/components/mcp23xxx_base/__init__.py b/esphome/components/mcp23xxx_base/__init__.py
index d6e82101adf..cd952099c05 100644
--- a/esphome/components/mcp23xxx_base/__init__.py
+++ b/esphome/components/mcp23xxx_base/__init__.py
@@ -5,6 +5,7 @@ from esphome.const import (
     CONF_ID,
     CONF_INPUT,
     CONF_INTERRUPT,
+    CONF_INTERRUPT_PIN,
     CONF_INVERTED,
     CONF_MODE,
     CONF_NUMBER,
@@ -32,6 +33,7 @@ MCP23XXX_INTERRUPT_MODES = {
 MCP23XXX_CONFIG_SCHEMA = cv.Schema(
     {
         cv.Optional(CONF_OPEN_DRAIN_INTERRUPT, default=False): cv.boolean,
+        cv.Optional(CONF_INTERRUPT_PIN): pins.internal_gpio_input_pin_schema,
     }
 ).extend(cv.COMPONENT_SCHEMA)
 
@@ -43,6 +45,8 @@ async def register_mcp23xxx(config, num_pins):
     await cg.register_component(var, config)
     CORE.data.setdefault(CONF_MCP23XXX, {})[id.id] = num_pins
     cg.add(var.set_open_drain_ints(config[CONF_OPEN_DRAIN_INTERRUPT]))
+    if interrupt_pin := config.get(CONF_INTERRUPT_PIN):
+        cg.add(var.set_interrupt_pin(await cg.gpio_pin_expression(interrupt_pin)))
     return var
 
 
diff --git a/esphome/components/mcp23xxx_base/mcp23xxx_base.h b/esphome/components/mcp23xxx_base/mcp23xxx_base.h
index fb992466d5d..9c50ee42f13 100644
--- a/esphome/components/mcp23xxx_base/mcp23xxx_base.h
+++ b/esphome/components/mcp23xxx_base/mcp23xxx_base.h
@@ -15,11 +15,28 @@ template<uint8_t N> class MCP23XXXBase : public Component, public gpio_expander:
   virtual void pin_interrupt_mode(uint8_t pin, MCP23XXXInterruptMode interrupt_mode);
 
   void set_open_drain_ints(const bool value) { this->open_drain_ints_ = value; }
+  void set_interrupt_pin(InternalGPIOPin *pin) { this->interrupt_pin_ = pin; }
   float get_setup_priority() const override { return setup_priority::IO; }
 
-  void loop() override { this->reset_pin_cache_(); }
+  void setup_interrupt_pin_() {
+    if (this->interrupt_pin_ != nullptr) {
+      this->interrupt_pin_->setup();
+      this->interrupt_pin_->attach_interrupt(&MCP23XXXBase::gpio_intr, this, gpio::INTERRUPT_FALLING_EDGE);
+      this->set_invalidate_on_read_(false);
+      this->disable_loop();
+    }
+  }
+
+  void loop() override {
+    this->reset_pin_cache_();
+    if (this->interrupt_pin_ != nullptr) {
+      this->disable_loop();
+    }
+  }
 
  protected:
+  static void IRAM_ATTR gpio_intr(MCP23XXXBase *arg) { arg->enable_loop_soon_any_context(); }
+
   // read a given register
   virtual bool read_reg(uint8_t reg, uint8_t *value) = 0;
   // write a value to a given register
@@ -28,6 +45,7 @@ template<uint8_t N> class MCP23XXXBase : public Component, public gpio_expander:
   virtual void update_reg(uint8_t pin, bool pin_value, uint8_t reg_a) = 0;
 
   bool open_drain_ints_;
+  InternalGPIOPin *interrupt_pin_{nullptr};
 };
 
 template<uint8_t N> class MCP23XXXGPIOPin : public GPIOPin {
diff --git a/esphome/components/pi4ioe5v6408/__init__.py b/esphome/components/pi4ioe5v6408/__init__.py
index c64f923823e..d5b19dab1c8 100644
--- a/esphome/components/pi4ioe5v6408/__init__.py
+++ b/esphome/components/pi4ioe5v6408/__init__.py
@@ -5,6 +5,7 @@ import esphome.config_validation as cv
 from esphome.const import (
     CONF_ID,
     CONF_INPUT,
+    CONF_INTERRUPT_PIN,
     CONF_INVERTED,
     CONF_MODE,
     CONF_NUMBER,
@@ -33,6 +34,7 @@ CONFIG_SCHEMA = (
         {
             cv.Required(CONF_ID): cv.declare_id(PI4IOE5V6408Component),
             cv.Optional(CONF_RESET, default=True): cv.boolean,
+            cv.Optional(CONF_INTERRUPT_PIN): pins.internal_gpio_input_pin_schema,
         }
     )
     .extend(cv.COMPONENT_SCHEMA)
@@ -46,6 +48,8 @@ async def to_code(config):
     await i2c.register_i2c_device(var, config)
 
     cg.add(var.set_reset(config[CONF_RESET]))
+    if interrupt_pin := config.get(CONF_INTERRUPT_PIN):
+        cg.add(var.set_interrupt_pin(await cg.gpio_pin_expression(interrupt_pin)))
 
 
 def validate_mode(value):
diff --git a/esphome/components/pi4ioe5v6408/pi4ioe5v6408.cpp b/esphome/components/pi4ioe5v6408/pi4ioe5v6408.cpp
index 9247e114f04..4155e52b393 100644
--- a/esphome/components/pi4ioe5v6408/pi4ioe5v6408.cpp
+++ b/esphome/components/pi4ioe5v6408/pi4ioe5v6408.cpp
@@ -33,9 +33,18 @@ void PI4IOE5V6408Component::setup() {
       return;
     }
   }
+
+  if (this->interrupt_pin_ != nullptr) {
+    this->interrupt_pin_->setup();
+    this->interrupt_pin_->attach_interrupt(&PI4IOE5V6408Component::gpio_intr, this, gpio::INTERRUPT_FALLING_EDGE);
+    this->set_invalidate_on_read_(false);
+    this->disable_loop();
+  }
 }
+void IRAM_ATTR PI4IOE5V6408Component::gpio_intr(PI4IOE5V6408Component *arg) { arg->enable_loop_soon_any_context(); }
 void PI4IOE5V6408Component::dump_config() {
   ESP_LOGCONFIG(TAG, "PI4IOE5V6408:");
+  LOG_PIN("  Interrupt Pin: ", this->interrupt_pin_);
   LOG_I2C_DEVICE(this)
   if (this->is_failed()) {
     ESP_LOGE(TAG, ESP_LOG_MSG_COMM_FAIL);
@@ -60,7 +69,12 @@ void PI4IOE5V6408Component::pin_mode(uint8_t pin, gpio::Flags flags) {
   this->write_gpio_modes_();
 }
 
-void PI4IOE5V6408Component::loop() { this->reset_pin_cache_(); }
+void PI4IOE5V6408Component::loop() {
+  this->reset_pin_cache_();
+  if (this->interrupt_pin_ != nullptr) {
+    this->disable_loop();
+  }
+}
 
 bool PI4IOE5V6408Component::read_gpio_outputs_() {
   if (this->is_failed())
diff --git a/esphome/components/pi4ioe5v6408/pi4ioe5v6408.h b/esphome/components/pi4ioe5v6408/pi4ioe5v6408.h
index 4dc31201ce4..ff2474fe994 100644
--- a/esphome/components/pi4ioe5v6408/pi4ioe5v6408.h
+++ b/esphome/components/pi4ioe5v6408/pi4ioe5v6408.h
@@ -22,8 +22,11 @@ class PI4IOE5V6408Component : public Component,
 
   /// Indicate if the component should reset the state during setup
   void set_reset(bool reset) { this->reset_ = reset; }
+  void set_interrupt_pin(InternalGPIOPin *pin) { this->interrupt_pin_ = pin; }
 
  protected:
+  static void IRAM_ATTR gpio_intr(PI4IOE5V6408Component *arg);
+
   bool digital_read_hw(uint8_t pin) override;
   bool digital_read_cache(uint8_t pin) override;
   void digital_write_hw(uint8_t pin, bool value) override;
@@ -40,6 +43,7 @@ class PI4IOE5V6408Component : public Component,
   uint8_t pull_up_down_mask_{0x00};
 
   bool reset_{true};
+  InternalGPIOPin *interrupt_pin_{nullptr};
 
   bool read_gpio_modes_();
   bool write_gpio_modes_();
diff --git a/tests/components/mcp23008/common.yaml b/tests/components/mcp23008/common.yaml
index 4a407adfd82..dfd543540d5 100644
--- a/tests/components/mcp23008/common.yaml
+++ b/tests/components/mcp23008/common.yaml
@@ -1,6 +1,10 @@
 mcp23008:
-  i2c_id: i2c_bus
-  id: mcp23008_hub
+  - i2c_id: i2c_bus
+    id: mcp23008_hub
+  - i2c_id: i2c_bus
+    id: mcp23008_hub_int
+    address: 0x21
+    interrupt_pin: ${interrupt_pin}
 
 binary_sensor:
   - platform: gpio
diff --git a/tests/components/mcp23008/test.esp32-idf.yaml b/tests/components/mcp23008/test.esp32-idf.yaml
index b47e39c3898..8c3b341dce0 100644
--- a/tests/components/mcp23008/test.esp32-idf.yaml
+++ b/tests/components/mcp23008/test.esp32-idf.yaml
@@ -1,3 +1,6 @@
+substitutions:
+  interrupt_pin: GPIO15
+
 packages:
   i2c: !include ../../test_build_components/common/i2c/esp32-idf.yaml
 
diff --git a/tests/components/mcp23008/test.esp8266-ard.yaml b/tests/components/mcp23008/test.esp8266-ard.yaml
index 4a98b9388ab..69b243bfd80 100644
--- a/tests/components/mcp23008/test.esp8266-ard.yaml
+++ b/tests/components/mcp23008/test.esp8266-ard.yaml
@@ -1,3 +1,6 @@
+substitutions:
+  interrupt_pin: GPIO15
+
 packages:
   i2c: !include ../../test_build_components/common/i2c/esp8266-ard.yaml
 
diff --git a/tests/components/mcp23008/test.rp2040-ard.yaml b/tests/components/mcp23008/test.rp2040-ard.yaml
index 319a7c71a65..b8ad1e47925 100644
--- a/tests/components/mcp23008/test.rp2040-ard.yaml
+++ b/tests/components/mcp23008/test.rp2040-ard.yaml
@@ -1,3 +1,6 @@
+substitutions:
+  interrupt_pin: GPIO2
+
 packages:
   i2c: !include ../../test_build_components/common/i2c/rp2040-ard.yaml
 
diff --git a/tests/components/mcp23017/common.yaml b/tests/components/mcp23017/common.yaml
index 54a97e911fe..2f90335e169 100644
--- a/tests/components/mcp23017/common.yaml
+++ b/tests/components/mcp23017/common.yaml
@@ -1,6 +1,10 @@
 mcp23017:
-  i2c_id: i2c_bus
-  id: mcp23017_hub
+  - i2c_id: i2c_bus
+    id: mcp23017_hub
+  - i2c_id: i2c_bus
+    id: mcp23017_hub_int
+    address: 0x21
+    interrupt_pin: ${interrupt_pin}
 
 binary_sensor:
   - platform: gpio
diff --git a/tests/components/mcp23017/test.esp32-idf.yaml b/tests/components/mcp23017/test.esp32-idf.yaml
index b47e39c3898..8c3b341dce0 100644
--- a/tests/components/mcp23017/test.esp32-idf.yaml
+++ b/tests/components/mcp23017/test.esp32-idf.yaml
@@ -1,3 +1,6 @@
+substitutions:
+  interrupt_pin: GPIO15
+
 packages:
   i2c: !include ../../test_build_components/common/i2c/esp32-idf.yaml
 
diff --git a/tests/components/mcp23017/test.esp8266-ard.yaml b/tests/components/mcp23017/test.esp8266-ard.yaml
index 4a98b9388ab..69b243bfd80 100644
--- a/tests/components/mcp23017/test.esp8266-ard.yaml
+++ b/tests/components/mcp23017/test.esp8266-ard.yaml
@@ -1,3 +1,6 @@
+substitutions:
+  interrupt_pin: GPIO15
+
 packages:
   i2c: !include ../../test_build_components/common/i2c/esp8266-ard.yaml
 
diff --git a/tests/components/mcp23017/test.rp2040-ard.yaml b/tests/components/mcp23017/test.rp2040-ard.yaml
index 319a7c71a65..b8ad1e47925 100644
--- a/tests/components/mcp23017/test.rp2040-ard.yaml
+++ b/tests/components/mcp23017/test.rp2040-ard.yaml
@@ -1,3 +1,6 @@
+substitutions:
+  interrupt_pin: GPIO2
+
 packages:
   i2c: !include ../../test_build_components/common/i2c/rp2040-ard.yaml
 
diff --git a/tests/components/mcp23s08/common.yaml b/tests/components/mcp23s08/common.yaml
index 2170ae04596..327bf02ca9b 100644
--- a/tests/components/mcp23s08/common.yaml
+++ b/tests/components/mcp23s08/common.yaml
@@ -2,3 +2,4 @@ mcp23s08:
   - id: mcp23s08_hub
     cs_pin: ${cs_pin}
     deviceaddress: 0
+    interrupt_pin: ${interrupt_pin}
diff --git a/tests/components/mcp23s08/test.esp32-idf.yaml b/tests/components/mcp23s08/test.esp32-idf.yaml
index a3352cf880d..eeb69416453 100644
--- a/tests/components/mcp23s08/test.esp32-idf.yaml
+++ b/tests/components/mcp23s08/test.esp32-idf.yaml
@@ -1,5 +1,6 @@
 substitutions:
   cs_pin: GPIO5
+  interrupt_pin: GPIO15
 
 packages:
   spi: !include ../../test_build_components/common/spi/esp32-idf.yaml
diff --git a/tests/components/mcp23s08/test.esp8266-ard.yaml b/tests/components/mcp23s08/test.esp8266-ard.yaml
index 595f31046ab..472fdb25821 100644
--- a/tests/components/mcp23s08/test.esp8266-ard.yaml
+++ b/tests/components/mcp23s08/test.esp8266-ard.yaml
@@ -1,5 +1,6 @@
 substitutions:
   cs_pin: GPIO15
+  interrupt_pin: GPIO13
 
 packages:
   spi: !include ../../test_build_components/common/spi/esp8266-ard.yaml
diff --git a/tests/components/mcp23s08/test.rp2040-ard.yaml b/tests/components/mcp23s08/test.rp2040-ard.yaml
index 79ea6ce90b0..09b87ca3f85 100644
--- a/tests/components/mcp23s08/test.rp2040-ard.yaml
+++ b/tests/components/mcp23s08/test.rp2040-ard.yaml
@@ -1,5 +1,6 @@
 substitutions:
   cs_pin: GPIO5
+  interrupt_pin: GPIO2
 
 packages:
   spi: !include ../../test_build_components/common/spi/rp2040-ard.yaml
diff --git a/tests/components/mcp23s17/common.yaml b/tests/components/mcp23s17/common.yaml
index a89beeb16b7..150ecca325d 100644
--- a/tests/components/mcp23s17/common.yaml
+++ b/tests/components/mcp23s17/common.yaml
@@ -2,3 +2,4 @@ mcp23s17:
   - id: mcp23s17_hub
     cs_pin: ${cs_pin}
     deviceaddress: 0
+    interrupt_pin: ${interrupt_pin}
diff --git a/tests/components/mcp23s17/test.esp32-idf.yaml b/tests/components/mcp23s17/test.esp32-idf.yaml
index a3352cf880d..eeb69416453 100644
--- a/tests/components/mcp23s17/test.esp32-idf.yaml
+++ b/tests/components/mcp23s17/test.esp32-idf.yaml
@@ -1,5 +1,6 @@
 substitutions:
   cs_pin: GPIO5
+  interrupt_pin: GPIO15
 
 packages:
   spi: !include ../../test_build_components/common/spi/esp32-idf.yaml
diff --git a/tests/components/mcp23s17/test.esp8266-ard.yaml b/tests/components/mcp23s17/test.esp8266-ard.yaml
index 595f31046ab..472fdb25821 100644
--- a/tests/components/mcp23s17/test.esp8266-ard.yaml
+++ b/tests/components/mcp23s17/test.esp8266-ard.yaml
@@ -1,5 +1,6 @@
 substitutions:
   cs_pin: GPIO15
+  interrupt_pin: GPIO13
 
 packages:
   spi: !include ../../test_build_components/common/spi/esp8266-ard.yaml
diff --git a/tests/components/mcp23s17/test.rp2040-ard.yaml b/tests/components/mcp23s17/test.rp2040-ard.yaml
index 79ea6ce90b0..09b87ca3f85 100644
--- a/tests/components/mcp23s17/test.rp2040-ard.yaml
+++ b/tests/components/mcp23s17/test.rp2040-ard.yaml
@@ -1,5 +1,6 @@
 substitutions:
   cs_pin: GPIO5
+  interrupt_pin: GPIO2
 
 packages:
   spi: !include ../../test_build_components/common/spi/rp2040-ard.yaml
diff --git a/tests/components/pi4ioe5v6408/common.yaml b/tests/components/pi4ioe5v6408/common.yaml
index 2344622081a..2c96fa0d9a4 100644
--- a/tests/components/pi4ioe5v6408/common.yaml
+++ b/tests/components/pi4ioe5v6408/common.yaml
@@ -1,7 +1,11 @@
 pi4ioe5v6408:
-  i2c_id: i2c_bus
-  id: pi4ioe1
-  address: 0x44
+  - i2c_id: i2c_bus
+    id: pi4ioe1
+    address: 0x44
+  - i2c_id: i2c_bus
+    id: pi4ioe1_int
+    address: 0x45
+    interrupt_pin: ${interrupt_pin}
 
 switch:
   - platform: gpio
diff --git a/tests/components/pi4ioe5v6408/test.esp32-idf.yaml b/tests/components/pi4ioe5v6408/test.esp32-idf.yaml
index 9a4779d822a..a6eb3c1cb14 100644
--- a/tests/components/pi4ioe5v6408/test.esp32-idf.yaml
+++ b/tests/components/pi4ioe5v6408/test.esp32-idf.yaml
@@ -1,6 +1,7 @@
 substitutions:
   i2c_sda: GPIO21
   i2c_scl: GPIO22
+  interrupt_pin: GPIO15
 
 packages:
   i2c: !include ../../test_build_components/common/i2c/esp32-idf.yaml
diff --git a/tests/components/pi4ioe5v6408/test.rp2040-ard.yaml b/tests/components/pi4ioe5v6408/test.rp2040-ard.yaml
index 3429a2952a3..cd6fef30421 100644
--- a/tests/components/pi4ioe5v6408/test.rp2040-ard.yaml
+++ b/tests/components/pi4ioe5v6408/test.rp2040-ard.yaml
@@ -1,6 +1,7 @@
 substitutions:
   i2c_sda: GPIO4
   i2c_scl: GPIO5
+  interrupt_pin: GPIO2
 
 packages:
   i2c: !include ../../test_build_components/common/i2c/rp2040-ard.yaml