diff --git a/esphome/components/usb_uart/__init__.py b/esphome/components/usb_uart/__init__.py
index eedf590ecae..2d85723d722 100644
--- a/esphome/components/usb_uart/__init__.py
+++ b/esphome/components/usb_uart/__init__.py
@@ -1,7 +1,7 @@
 import esphome.codegen as cg
 from esphome.components import socket
 from esphome.components.const import CONF_DATA_BITS, CONF_PARITY, CONF_STOP_BITS
-from esphome.components.uart import CONF_DEBUG_PREFIX, UARTComponent
+from esphome.components.uart import CONF_DEBUG_PREFIX, CONF_FLUSH_TIMEOUT, UARTComponent
 from esphome.components.usb_host import register_usb_client, usb_device_schema
 import esphome.config_validation as cv
 from esphome.const import (
@@ -91,6 +91,9 @@ def channel_schema(channels, baud_rate_required):
                             cv.Optional(CONF_DUMMY_RECEIVER, default=False): cv.boolean,
                             cv.Optional(CONF_DEBUG, default=False): cv.boolean,
                             cv.Optional(CONF_DEBUG_PREFIX, default=""): cv.string,
+                            cv.Optional(
+                                CONF_FLUSH_TIMEOUT, default="100ms"
+                            ): cv.positive_time_period_milliseconds,
                         }
                     )
                 ),
@@ -129,6 +132,7 @@ async def to_code(config):
             cg.add(chvar.set_parity(channel[CONF_PARITY]))
             cg.add(chvar.set_baud_rate(channel[CONF_BAUD_RATE]))
             cg.add(chvar.set_dummy_receiver(channel[CONF_DUMMY_RECEIVER]))
+            cg.add(chvar.set_flush_timeout(channel[CONF_FLUSH_TIMEOUT]))
             cg.add(chvar.set_debug(channel[CONF_DEBUG]))
             if channel[CONF_DEBUG_PREFIX]:
                 cg.add(chvar.set_debug_prefix(channel[CONF_DEBUG_PREFIX]))
diff --git a/esphome/components/usb_uart/usb_uart.cpp b/esphome/components/usb_uart/usb_uart.cpp
index a0101a55463..83de0b39fcc 100644
--- a/esphome/components/usb_uart/usb_uart.cpp
+++ b/esphome/components/usb_uart/usb_uart.cpp
@@ -169,10 +169,10 @@ void USBUartChannel::write_array(const uint8_t *data, size_t len) {
 uart::FlushResult USBUartChannel::flush() {
   // Spin until the output queue is drained and the last USB transfer completes.
   // Safe to call from the main loop only.
-  // The 100 ms timeout guards against a device that stops responding mid-flush;
+  // The flush_timeout_ms_ timeout guards against a device that stops responding mid-flush;
   // in that case the main loop is blocked for the full duration.
-  uint32_t start = millis();  // 100 ms safety timeout
-  while ((!this->output_queue_.empty() || this->output_started_.load()) && millis() - start < 100) {
+  uint32_t start = millis();
+  while ((!this->output_queue_.empty() || this->output_started_.load()) && millis() - start < this->flush_timeout_ms_) {
     // Kick start_output() in case data arrived but no transfer is in flight yet.
     this->parent_->start_output(this);
     yield();
@@ -260,10 +260,12 @@ void USBUartComponent::dump_config() {
                   "    Data Bits: %u\n"
                   "    Parity: %s\n"
                   "    Stop bits: %s\n"
+                  "    Flush Timeout: %" PRIu32 " ms\n"
                   "    Debug: %s\n"
                   "    Dummy receiver: %s",
                   channel->index_, channel->baud_rate_, channel->data_bits_, PARITY_NAMES[channel->parity_],
-                  STOP_BITS_NAMES[channel->stop_bits_], YESNO(channel->debug_), YESNO(channel->dummy_receiver_));
+                  STOP_BITS_NAMES[channel->stop_bits_], channel->flush_timeout_ms_, YESNO(channel->debug_),
+                  YESNO(channel->dummy_receiver_));
   }
 }
 void USBUartComponent::start_input(USBUartChannel *channel) {
diff --git a/esphome/components/usb_uart/usb_uart.h b/esphome/components/usb_uart/usb_uart.h
index 671f0cab8c0..b1748aebf28 100644
--- a/esphome/components/usb_uart/usb_uart.h
+++ b/esphome/components/usb_uart/usb_uart.h
@@ -116,6 +116,7 @@ class USBUartChannel : public uart::UARTComponent, public Parented<USBUartCompon
   void set_debug(bool debug) { this->debug_ = debug; }
   void set_dummy_receiver(bool dummy_receiver) { this->dummy_receiver_ = dummy_receiver; }
   void set_debug_prefix(const char *prefix) { this->debug_prefix_ = StringRef(prefix); }
+  void set_flush_timeout(uint32_t flush_timeout_ms) override { this->flush_timeout_ms_ = flush_timeout_ms; }
 
   /// Register a callback invoked immediately after data is pushed to the input ring buffer.
   /// Called from USBUartComponent::loop() in the main loop context.
@@ -124,23 +125,23 @@ class USBUartChannel : public uart::UARTComponent, public Parented<USBUartCompon
   void set_rx_callback(std::function<void()> cb) { this->rx_callback_ = std::move(cb); }
 
  protected:
-  // Larger structures first for better alignment
+  // Larger structures first (8+ bytes)
   RingBuffer input_buffer_;
   LockFreeQueue<UsbOutputChunk, USB_OUTPUT_CHUNK_COUNT> output_queue_;
   EventPool<UsbOutputChunk, USB_OUTPUT_CHUNK_COUNT> output_pool_;
   std::function<void()> rx_callback_{};
   CdcEps cdc_dev_{};
-  // Enum (likely 4 bytes)
+  StringRef debug_prefix_{};
+  // 4-byte fields
   UARTParityOptions parity_{UART_CONFIG_PARITY_NONE};
-  // Group atomics together (each 1 byte)
+  uint32_t flush_timeout_ms_{100};
+  // 1-byte fields (no padding between groups)
   std::atomic<bool> input_started_{true};
   std::atomic<bool> output_started_{true};
   std::atomic<bool> initialised_{false};
-  // Group regular bytes together to minimize padding
   const uint8_t index_;
   bool debug_{};
   bool dummy_receiver_{};
-  StringRef debug_prefix_{};
 };
 
 class USBUartComponent : public usb_host::USBClient {