diff --git a/esphome/components/gpio/switch/__init__.py b/esphome/components/gpio/switch/__init__.py
index 604de6d809..9462cd0161 100644
--- a/esphome/components/gpio/switch/__init__.py
+++ b/esphome/components/gpio/switch/__init__.py
@@ -32,6 +32,7 @@ async def to_code(config):
     cg.add(var.set_pin(pin))
 
     if CONF_INTERLOCK in config:
+        cg.add_define("USE_GPIO_SWITCH_INTERLOCK")
         interlock = []
         for it in config[CONF_INTERLOCK]:
             lock = await cg.get_variable(it)
diff --git a/esphome/components/gpio/switch/gpio_switch.cpp b/esphome/components/gpio/switch/gpio_switch.cpp
index d461fab051..9c6464815a 100644
--- a/esphome/components/gpio/switch/gpio_switch.cpp
+++ b/esphome/components/gpio/switch/gpio_switch.cpp
@@ -5,7 +5,9 @@ namespace esphome {
 namespace gpio {
 
 static const char *const TAG = "switch.gpio";
+#ifdef USE_GPIO_SWITCH_INTERLOCK
 static constexpr uint32_t INTERLOCK_TIMEOUT_ID = 0;
+#endif
 
 float GPIOSwitch::get_setup_priority() const { return setup_priority::HARDWARE; }
 void GPIOSwitch::setup() {
@@ -28,6 +30,7 @@ void GPIOSwitch::setup() {
 void GPIOSwitch::dump_config() {
   LOG_SWITCH("", "GPIO Switch", this);
   LOG_PIN("  Pin: ", this->pin_);
+#ifdef USE_GPIO_SWITCH_INTERLOCK
   if (!this->interlock_.empty()) {
     ESP_LOGCONFIG(TAG, "  Interlocks:");
     for (auto *lock : this->interlock_) {
@@ -36,8 +39,10 @@ void GPIOSwitch::dump_config() {
       ESP_LOGCONFIG(TAG, "    %s", lock->get_name().c_str());
     }
   }
+#endif
 }
 void GPIOSwitch::write_state(bool state) {
+#ifdef USE_GPIO_SWITCH_INTERLOCK
   if (state != this->inverted_) {
     // Turning ON, check interlocking
 
@@ -64,11 +69,15 @@ void GPIOSwitch::write_state(bool state) {
     // re-activations
     this->cancel_timeout(INTERLOCK_TIMEOUT_ID);
   }
+#endif
 
   this->pin_->digital_write(state);
   this->publish_state(state);
 }
+
+#ifdef USE_GPIO_SWITCH_INTERLOCK
 void GPIOSwitch::set_interlock(const std::initializer_list<Switch *> &interlock) { this->interlock_ = interlock; }
+#endif
 
 }  // namespace gpio
 }  // namespace esphome
diff --git a/esphome/components/gpio/switch/gpio_switch.h b/esphome/components/gpio/switch/gpio_switch.h
index a73fb9e18c..f7415d1dba 100644
--- a/esphome/components/gpio/switch/gpio_switch.h
+++ b/esphome/components/gpio/switch/gpio_switch.h
@@ -18,15 +18,19 @@ class GPIOSwitch final : public switch_::Switch, public Component {
 
   void setup() override;
   void dump_config() override;
+#ifdef USE_GPIO_SWITCH_INTERLOCK
   void set_interlock(const std::initializer_list<Switch *> &interlock);
   void set_interlock_wait_time(uint32_t interlock_wait_time) { interlock_wait_time_ = interlock_wait_time; }
+#endif
 
  protected:
   void write_state(bool state) override;
 
   GPIOPin *pin_;
+#ifdef USE_GPIO_SWITCH_INTERLOCK
   FixedVector<Switch *> interlock_;
   uint32_t interlock_wait_time_{0};
+#endif
 };
 
 }  // namespace gpio
diff --git a/esphome/core/defines.h b/esphome/core/defines.h
index d94b7e9f5d..f437e30a95 100644
--- a/esphome/core/defines.h
+++ b/esphome/core/defines.h
@@ -53,6 +53,7 @@
 #define USE_ESP32_IMPROV_STATE_CALLBACK
 #define USE_EVENT
 #define USE_FAN
+#define USE_GPIO_SWITCH_INTERLOCK
 #define USE_GRAPH
 #define USE_GRAPHICAL_DISPLAY_MENU
 #define USE_HOMEASSISTANT_TIME